A.M. Edwards

Research interests

Publications

• A proposal for validation of antibodies

  Nature Methods · 2016 · https://doi.org/10.1038/nmeth.3995

• The promise and peril of chemical probes

  Nature Chemical Biology · 2015 · https://doi.org/10.1038/nchembio.1867

• A Call for Systematic Research on Solute Carriers

  Cell · 2015 · https://doi.org/10.1016/j.cell.2015.07.022

• Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

  Proceedings of the National Academy of Sciences · 2013 · 10.1073/pnas.1217042110

• Too many roads not taken

  Nature · 2011 · 10.1038/470163a

• The human genome and drug discovery after a decade. Roads (still) not taken

  arXiv (Cornell University) · 2011 · 10.48550/arxiv.1102.0448

• A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

  Nature Chemical Biology · 2011 · 10.1038/nchembio.599

• Structure and Biochemical Functions of SIRT6

  Journal of Biological Chemistry · 2011 · 10.1074/jbc.m111.218990

• A dual function of the CRISPR–Cas system in bacterial antivirus immunity and DNA repair

  Molecular Microbiology · 2010 · 10.1111/j.1365-2958.2010.07465.x

• Structural and Chemical Profiling of the Human Cytosolic Sulfotransferases

  PLoS Biology · 2007 · 10.1371/journal.pbio.0050097

• Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination

  Proceedings of the National Academy of Sciences · 2006 · https://doi.org/10.1073/pnas.0605224103

• Genome-wide Analysis of Substrate Specificities of the Escherichia coli Haloacid Dehalogenase-like Phosphatase Family

  Journal of Biological Chemistry · 2006 · 10.1074/jbc.m605449200

• Crystal structure of the CorA Mg2+ transporter

  Nature · 2006 · 10.1038/nature04642

• Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms

  Molecular and Biochemical Parasitology · 2006 · 10.1016/j.molbiopara.2006.10.011

• Protein folding: Defining a “standard” set of experimental conditions and a preliminary kinetic data set of two‐state proteins

  Protein Science · 2005 · 10.1110/ps.041205405

• Hepatic Gene Expression Discriminates Responders and Nonresponders in Treatment of Chronic Hepatitis C Viral Infection

  Gastroenterology · 2005 · 10.1053/j.gastro.2005.01.059

• The Drosophila Nuclear Receptor E75 Contains Heme and Is Gas Responsive

  Cell · 2005 · 10.1016/j.cell.2005.07.005

• Structure of the p53 Binding Domain of HAUSP/USP7 Bound to Epstein-Barr Nuclear Antigen 1

  Molecular Cell · 2005 · 10.1016/j.molcel.2005.02.029

• Bridging structural biology and genomics: assessing protein interaction data with known complexes

  Trends in Genetics · 2002 · 10.1016/s0168-9525(02)02763-4

• Herpes Simplex Virus Triggers and Then Disarms a Host Antiviral Response

  Journal of Virology · 2001 · 10.1128/jvi.75.2.750-758.2001

• Structural proteomics of an archaeon.

  Nature Structural Biology · 2000 · 10.1038/82823

• Structural Basis for the Recognition of DNA Repair Proteins UNG2, XPA, and RAD52 by Replication Factor RPA

  Cell · 2000 · 10.1016/s0092-8674(00)00136-7

• Architecture of RNA Polymerase II and Implications for the Transcription Mechanism

  Science · 2000 · https://doi.org/10.1126/science.288.5466.640

• Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA

  Nature · 1997 · 10.1038/385176a0

• Two dissociable subunits of yeast RNA polymerase II stimulate the initiation of transcription at a promoter in vitro.

  Journal of Biological Chemistry · 1991 · 10.1016/s0021-9258(18)52403-0

Current projects

No projects listed.