Geoffrey Liu

Research interests

Publications

• Datopotamab Deruxtecan Versus Docetaxel for Previously Treated Advanced or Metastatic Non–Small Cell Lung Cancer: The Randomized, Open-Label Phase III TROPION-Lung01 Study

  Journal of Clinical Oncology · 2024 · https://doi.org/10.1200/jco-24-01544

• Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer

  Nature Genetics · 2022 · https://doi.org/10.1038/s41588-022-01115-x

• First-Line Lorlatinib or Crizotinib in Advanced ALK -Positive Lung Cancer

  New England Journal of Medicine · 2020 · https://doi.org/10.1056/nejmoa2027187

• Organoid Cultures as Preclinical Models of Non–Small Cell Lung Cancer

  Clinical Cancer Research · 2019 · https://doi.org/10.1158/1078-0432.ccr-19-1376

• Organoid Cultures as Preclinical Models of Non–Small Cell Lung Cancer

  Clinical Cancer Research · 2019 · https://doi.org/10.1158/1078-0432.ccr-19-1376

• Sensitive tumour detection and classification using plasma cell-free DNA methylomes

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0703-0

• Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

  Nature Genetics · 2017 · https://doi.org/10.1038/ng.3892

• Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study

  PLoS ONE · 2017 · https://doi.org/10.1371/journal.pone.0177875

• Ceritinib versus chemotherapy in patients with ALK-rearranged non-small-cell lung cancer previously given chemotherapy and crizotinib (ASCEND-5): a randomised, controlled, open-label, phase 3 trial

  The Lancet Oncology · 2017 · https://doi.org/10.1016/s1470-2045(17)30339-x

• Uncommon EGFR mutations in advanced non-small cell lung cancer

  Lung Cancer · 2017 · https://doi.org/10.1016/j.lungcan.2017.04.016

• Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis

  The Lancet Oncology · 2016 · https://doi.org/10.1016/s1470-2045(16)30240-6

• Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3685

• Activity and safety of ceritinib in patients with ALK-rearranged non-small-cell lung cancer (ASCEND-1): updated results from the multicentre, open-label, phase 1 trial

  The Lancet Oncology · 2016 · https://doi.org/10.1016/s1470-2045(15)00614-2

• Ceritinib in ALK -Rearranged Non–Small-Cell Lung Cancer

  New England Journal of Medicine · 2014 · https://doi.org/10.1056/nejmoa1311107

• Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

  Nature Genetics · 2014 · https://doi.org/10.1038/ng.3002

• Obesity and Risk of Esophageal Adenocarcinoma and Barrett’s Esophagus: A Mendelian Randomization Study

  JNCI Journal of the National Cancer Institute · 2014 · https://doi.org/10.1093/jnci/dju252

• A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2796

• Validation of a Histology-Independent Prognostic Gene Signature for Early-Stage, Non–Small-Cell Lung Cancer Including Stage IA Patients

  Journal of Thoracic Oncology · 2013 · https://doi.org/10.1097/jto.0000000000000042

• Probability of Cancer in Pulmonary Nodules Detected on First Screening CT

  New England Journal of Medicine · 2013 · https://doi.org/10.1056/nejmoa1214726

• Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus

  Nature Genetics · 2012 · https://doi.org/10.1038/ng.2408

• Prognostic and Predictive Gene Signature for Adjuvant Chemotherapy in Resected Non–Small-Cell Lung Cancer

  Journal of Clinical Oncology · 2010 · https://doi.org/10.1200/jco.2009.26.4325

• Replication of Lung Cancer Susceptibility Loci at Chromosomes 15q25, 5p15, and 6p21: A Pooled Analysis From the International Lung Cancer Consortium

  JNCI Journal of the National Cancer Institute · 2010 · https://doi.org/10.1093/jnci/djq178

• A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

  Nature · 2008 · https://doi.org/10.1038/nature06885

• Three-Gene Prognostic Classifier for Early-Stage Non–Small-Cell Lung Cancer

  Journal of Clinical Oncology · 2007 · https://doi.org/10.1200/jco.2007.12.0352

• Erlotinib in Lung Cancer — Molecular and Clinical Predictors of Outcome

  New England Journal of Medicine · 2005 · https://doi.org/10.1056/nejmoa050736

• Molecular profiling of non-small cell lung cancer and correlation with disease-free survival.

  PubMed · 2002

Current projects

No projects listed.