Trevor J. Pugh

Research interests

Publications

• Analysis and Visualization of Longitudinal Genomic and Clinical Data from the AACR Project GENIE Biopharma Collaborative in cBioPortal

  Cancer Research · 2023 · https://doi.org/10.1158/0008-5472.can-23-0816

• Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity

  Immunity · 2022 · https://doi.org/10.1016/j.immuni.2022.01.006

• Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

  Cell · 2021 · https://doi.org/10.1016/j.cell.2020.11.018

• Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity

  Nature Cancer · 2021 · https://doi.org/10.1038/s43018-020-00154-9

• Personalized circulating tumor DNA analysis as a predictive biomarker in solid tumor patients treated with pembrolizumab

  Nature Cancer · 2020 · https://doi.org/10.1038/s43018-020-0096-5

• Childhood cerebellar tumours mirror conserved fetal transcriptional programs

  Nature · 2019 · https://doi.org/10.1038/s41586-019-1158-7

• Prediction of acute myeloid leukaemia risk in healthy individuals

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0317-6

• Sensitive tumour detection and classification using plasma cell-free DNA methylomes

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0703-0

• DNA hypermethylation within TERT promoter upregulates TERT expression in cancer

  Journal of Clinical Investigation · 2018 · https://doi.org/10.1172/jci121303

• Recurrent and functional regulatory mutations in breast cancer

  Nature · 2017 · https://doi.org/10.1038/nature22992

• Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

  Nature · 2017 · https://doi.org/10.1038/nature23666

• AACR Project GENIE: Powering Precision Medicine through an International Consortium

  Cancer Discovery · 2017 · https://doi.org/10.1158/2159-8290.cd-17-0151

• Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial

  Genome Medicine · 2016 · https://doi.org/10.1186/s13073-016-0364-2

• Divergent clonal selection dominates medulloblastoma at recurrence

  Nature · 2016 · https://doi.org/10.1038/nature16478

• The genomic landscape of schwannoma

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3688

• Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations

  Nature Genetics · 2015 · https://doi.org/10.1038/ng.3333

• Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

  Nature · 2014 · https://doi.org/10.1038/nature13108

• Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

  Cancer Cell · 2014 · https://doi.org/10.1016/j.ccr.2014.02.004

• Subgroup-Specific Prognostic Implications of TP53 Mutation in Medulloblastoma

  Journal of Clinical Oncology · 2013 · https://doi.org/10.1200/jco.2012.48.5052

• Mutational heterogeneity in cancer and the search for new cancer-associated genes

  Nature · 2013 · https://doi.org/10.1038/nature12213

• Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors

  Cancer Discovery · 2013 · 10.1158/2159-8290.cd-13-0310

• The genetic landscape of high-risk neuroblastoma

  Nature Genetics · 2013 · 10.1038/ng.2529

• Landscape of genomic alterations in cervical carcinomas

  Nature · 2013 · https://doi.org/10.1038/nature12881

• Dissecting the genomic complexity underlying medulloblastoma

  Nature · 2012 · https://doi.org/10.1038/nature11284

• Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing

  Cell · 2012 · 10.1016/j.cell.2012.08.029

• Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

  Nature · 2012 · 10.1038/nature11329

• The genomic complexity of primary human prostate cancer

  Nature · 2011 · 10.1038/nature09744

• Initial genome sequencing and analysis of multiple myeloma

  Nature · 2011 · 10.1038/nature09837

• Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

  Nature · 2009 · 10.1038/nature08489

• Oligonucleotide Microarray Analysis of Genomic Imbalance in Children with Mental Retardation

  The American Journal of Human Genetics · 2006 · https://doi.org/10.1086/507471

Current projects

No projects listed.