Mark D. Minden

Research interests

Publications

• A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia

  Nature Medicine · 2022 · 10.1038/s41591-022-01819-x

• Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality

  Cancer Cell · 2019 · 10.1016/j.ccell.2019.03.014

• PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia

  Nature Genetics · 2019 · https://doi.org/10.1038/s41588-018-0315-5

• A novel chimeric antigen receptor containing a JAK–STAT signaling domain mediates superior antitumor effects

  Nature Medicine · 2018 · 10.1038/nm.4478

• Sensitive tumour detection and classification using plasma cell-free DNA methylomes

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0703-0

• Prediction of acute myeloid leukaemia risk in healthy individuals

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0317-6

• Tracing the origins of relapse in acute myeloid leukaemia to stem cells

  Nature · 2017 · 10.1038/nature22993

• High Frequency and Poor Outcome of Philadelphia Chromosome–Like Acute Lymphoblastic Leukemia in Adults

  Journal of Clinical Oncology · 2017 · https://doi.org/10.1200/jco.2016.69.0073

• A 17-gene stemness score for rapid determination of risk in acute leukaemia

  Nature · 2016 · https://doi.org/10.1038/nature20598

• Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia

  Nature Communications · 2016 · 10.1038/ncomms13331

• International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts

  Blood · 2015 · https://doi.org/10.1182/blood-2015-01-621664

• AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

  Blood · 2015 · 10.1182/blood-2014-08-594408

• Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

  Nature · 2014 · https://doi.org/10.1038/nature13038

• The genomic landscape of hypodiploid acute lymphoblastic leukemia

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2532

• Multicenter, Randomized, Open-Label, Phase III Trial of Decitabine Versus Patient Choice, With Physician Advice, of Either Supportive Care or Low-Dose Cytarabine for the Treatment of Older Patients With Newly Diagnosed Acute Myeloid Leukemia

  Journal of Clinical Oncology · 2012 · https://doi.org/10.1200/jco.2011.38.9429

• Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

  Nature Medicine · 2012 · 10.1038/nm.2661

• Stem cell gene expression programs influence clinical outcome in human leukemia

  Nature Medicine · 2011 · 10.1038/nm.2415

• Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

  Cancer Cell · 2011 · 10.1016/j.ccr.2011.10.015

• Evolution of human BCR–ABL1 lymphoblastic leukaemia-initiating cells

  Nature · 2011 · 10.1038/nature09733

• Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

  The Journal of Experimental Medicine · 2010 · 10.1084/jem.20092506

• A tumor suppressor and oncogene: the WT1 story

  Leukemia · 2007 · 10.1038/sj.leu.2404624

• Myelodysplastic syndromes: the complexity of stem-cell diseases

  Nature reviews. Cancer · 2007 · 10.1038/nrc2047

• MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

  Nature Genetics · 2001 · https://doi.org/10.1038/ng765

• A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

  Nature · 1994 · https://doi.org/10.1038/367645a0

• Deregulation of a Homeobox Gene, HOX11, by the t(10;14) in T Cell Leukemia

  Science · 1991 · 10.1126/science.1676542

Current projects

No projects listed.