Geoffrey N. Hendy

Research interests

Publications

• Calcium-sensing receptor, proinflammatory cytokines and calcium homeostasis

  Seminars in Cell and Developmental Biology · 2015 · https://doi.org/10.1016/j.semcdb.2015.11.006

• The calcium-sensing receptor in bone—mechanistic and therapeutic insights

  Nature Reviews Endocrinology · 2015 · https://doi.org/10.1038/nrendo.2015.30

• The Proinflammatory Cytokine, Interleukin-6, Up-regulates Calcium-sensing Receptor Gene Transcription via Stat1/3 and Sp1/3

  Journal of Biological Chemistry · 2008 · https://doi.org/10.1074/jbc.m708087200

• Functional characterization of GATA3 mutations causing the hypoparathyroidism-deafness-renal (HDR) dysplasia syndrome: insight into mechanisms of DNA binding by the GATA3 transcription factor

  Human Molecular Genetics · 2006 · https://doi.org/10.1093/hmg/ddl454

• Calcium Sensing Receptor in Human Colon Carcinoma: Interaction with Ca2+ and 1,25-Dihydroxyvitamin D3

  Cancer Research · 2005 · https://doi.org/10.1158/0008-5472.493.65.2

• Inactivation of the 25-Hydroxyvitamin D 1α-Hydroxylase and Vitamin D Receptor Demonstrates Independent and Interdependent Effects of Calcium and Vitamin D on Skeletal and Mineral Homeostasis

  Journal of Biological Chemistry · 2004 · https://doi.org/10.1074/jbc.m310271200

• Menin Is Required for Bone Morphogenetic Protein 2- and Transforming Growth Factor β-regulated Osteoblastic Differentiation through Interaction with Smads and Runx2

  Journal of Biological Chemistry · 2004 · https://doi.org/10.1074/jbc.m401312200

• CASRdb: calcium-sensing receptor locus-specific database for mutations causing familial (benign) hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia

  Human Mutation · 2004 · https://doi.org/10.1002/humu.20067

• Familial Isolated Hyperparathyroidism Is Rarely Caused by Germline Mutation inHRPT2, the Gene for the Hyperparathyroidism-Jaw Tumor Syndrome

  The Journal of Clinical Endocrinology & Metabolism · 2004 · https://doi.org/10.1210/jc.2003-030675

• Autosomal dominant pseudohypoparathyroidism type Ib is associated with a heterozygous microdeletion that likely disrupts a putative imprinting control element of GNAS

  Journal of Clinical Investigation · 2003 · https://doi.org/10.1172/jci19159

• A Syndrome of Hypocalciuric Hypercalcemia Caused by Autoantibodies Directed at the Calcium-Sensing Receptor

  The Journal of Clinical Endocrinology & Metabolism · 2003 · https://doi.org/10.1210/jc.2002-020249

• Familial Isolated Hyperparathyroidism

  Medicine · 2002 · https://doi.org/10.1097/00005792-200201000-00001

• Human Calcium-sensing Receptor Gene

  Journal of Biological Chemistry · 2002 · https://doi.org/10.1074/jbc.m201804200

• Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type β signaling

  Proceedings of the National Academy of Sciences · 2001 · https://doi.org/10.1073/pnas.061358098

• Targeted ablation of the 25-hydroxyvitamin D 1α-hydroxylase enzyme: Evidence for skeletal, reproductive, and immune dysfunction

  Proceedings of the National Academy of Sciences · 2001 · https://doi.org/10.1073/pnas.131029498

• Mutations of the calcium-sensing receptor (CASR) in familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia

  Human Mutation · 2000 · https://doi.org/10.1002/1098-1004(200010)16:4<281::aid-humu1>3.0.co;2-a

• A986S polymorphism of the calcium-sensing receptor and circulating calcium concentrations

  The Lancet · 1999 · https://doi.org/10.1016/s0140-6736(98)06434-4

• The gene responsible for pseudohypoparathyroidism type Ib is paternally imprinted and maps in four unrelated kindreds to chromosome 20q13.3

  Proceedings of the National Academy of Sciences · 1998 · https://doi.org/10.1073/pnas.95.20.11798

• Insertion of an Alu sequence in the Ca(2+)-sensing receptor gene in familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism.

  PubMed · 1995

• Familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Effects of mutant gene dosage on phenotype.

  Journal of Clinical Investigation · 1994 · https://doi.org/10.1172/jci117062

• X-linked nephrogenic diabetes insipidus mutations in North America and the Hopewell hypothesis.

  Journal of Clinical Investigation · 1993 · https://doi.org/10.1172/jci116698

• Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidus

  Nature · 1992 · https://doi.org/10.1038/359233a0

• Circulating concentrations of parathyroid hormone-like peptide in malignancy and in hyperparathyroidism

  Journal of Bone and Mineral Research · 1990 · https://doi.org/10.1002/jbmr.5650050203

• Influence of Calcium and 1,25-Dihydroxycholecalciferol on Proliferation and Proto-Oncogene Expression in Primary Cultures of Bovine Parathyroid Cells*

  Endocrinology · 1989 · https://doi.org/10.1210/endo-125-2-935

• Characterization of the human parathyroid hormone-like peptide gene

  Journal of Biological Chemistry · 1989 · https://doi.org/10.1016/s0021-9258(18)83294-x

Current projects

No projects listed.