John A. Smith

Research interests

Publications

• Cough hypersensitivity and chronic cough

  Nature Reviews Disease Primers · 2022 · 10.1038/s41572-022-00370-w

• Efficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials

  The Lancet · 2022 · 10.1016/s0140-6736(21)02348-5

• A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-019-13825-8

• Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial

  The Lancet Respiratory Medicine · 2020 · https://doi.org/10.1016/s2213-2600(20)30511-7

• ERS guidelines on the diagnosis and treatment of chronic cough in adults and children

  European Respiratory Journal · 2019 · 10.1183/13993003.01136-2019

• Treatment of Unexplained Chronic Cough

  CHEST Journal · 2015 · https://doi.org/10.1378/chest.15-1496

• A worldwide survey of chronic cough: a manifestation of enhanced somatosensory response

  European Respiratory Journal · 2014 · 10.1183/09031936.00217813

• Anatomy and Neurophysiology of Cough

  CHEST Journal · 2014 · 10.1378/chest.14-1481

• Anatomy and Neurophysiology of Cough

  CHEST Journal · 2014 · 10.1378/chest.14-1481

• P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study

  The Lancet · 2014 · 10.1016/s0140-6736(14)61255-1

• Expert opinion on the cough hypersensitivity syndrome in respiratory medicine

  European Respiratory Journal · 2014 · https://doi.org/10.1183/09031936.00218613

• High-frequency Triazole Resistance Found In Nonculturable Aspergillus fumigatus from Lungs of Patients with Chronic Fungal Disease

  Clinical Infectious Diseases · 2011 · 10.1093/cid/cir179

• ERS guidelines on the assessment of cough

  European Respiratory Journal · 2007 · https://doi.org/10.1183/09031936.00101006

• Gestational stress induces post-partum depression-like behaviour and alters maternal care in rats

  Psychoneuroendocrinology · 2003 · 10.1016/s0306-4530(03)00025-8

• Neutrophils, host defense, and inflammation: a double-edged sword

  Journal of Leukocyte Biology · 1994 · 10.1002/jlb.56.6.672

• High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons.

  Proceedings of the National Academy of Sciences · 1989 · 10.1073/pnas.86.6.1836

• Prediction of major histocompatibility complex binding regions of protein antigens by sequence pattern analysis.

  Proceedings of the National Academy of Sciences · 1989 · 10.1073/pnas.86.9.3296

• Rapid separation and purification of oligonucleotides by high-performance capillary gel electrophoresis.

  Proceedings of the National Academy of Sciences · 1988 · https://doi.org/10.1073/pnas.85.24.9660

• Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis.

  The Journal of Experimental Medicine · 1988 · 10.1084/jem.168.5.1699

• High-performance capillary electrophoretic separation of bases, nucleosides, and oligonucleotides: retention manipulation via micellar solutions and metal additives

  Analytical Chemistry · 1987 · https://doi.org/10.1021/ac00134a020

• Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells

  Nature · 1987 · 10.1038/328395a0

• Identification of a putative second T-cell receptor

  Nature · 1986 · 10.1038/322145a0

• Antigenic determinants in proteins coincide with surface regions accessible to large probes (antibody domains).

  Proceedings of the National Academy of Sciences · 1986 · 10.1073/pnas.83.2.226

• Turns in Peptides and Proteins

  Advances in protein chemistry · 1985 · 10.1016/s0065-3233(08)60063-7

• Reverse Turns in Peptides and Protein

  Critical Reviews in Biochemistry and Molecular Biology · 1980 · 10.3109/10409238009105470

• A comparative randomized trial of heparin versus streptokinase in the treatment of acute proximal venous thrombosis: An interim report of a prospective trial

  British journal of surgery · 1979 · 10.1002/bjs.1800661203

Current projects

No projects listed.