Natasha B. Leighl

Research interests

Publications

• Amivantamab in EGFR Exon 20 Insertion–Mutated Non–Small-Cell Lung Cancer Progressing on Platinum Chemotherapy: Initial Results From the CHRYSALIS Phase I Study

  Journal of Clinical Oncology · 2021 · 10.1200/jco.21.00662

• Liquid Biopsy for Advanced NSCLC: A Consensus Statement From the International Association for the Study of Lung Cancer

  Journal of Thoracic Oncology · 2021 · https://doi.org/10.1016/j.jtho.2021.06.017

• Therapy for Stage IV Non–Small-Cell Lung Cancer With Driver Alterations: ASCO and OH (CCO) Joint Guideline Update

  Journal of Clinical Oncology · 2021 · 10.1200/jco.20.03570

• Therapy for Stage IV Non–Small-Cell Lung Cancer Without Driver Alterations: ASCO and OH (CCO) Joint Guideline Update

  Journal of Clinical Oncology · 2020 · 10.1200/jco.19.03022

• Clinical Utility of Comprehensive Cell-free DNA Analysis to Identify Genomic Biomarkers in Patients with Newly Diagnosed Metastatic Non–small Cell Lung Cancer

  Clinical Cancer Research · 2019 · 10.1158/1078-0432.ccr-19-0624

• Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline

  Journal of Clinical Oncology · 2018 · 10.1200/jco.2017.77.6385

• Molecular Testing Guideline for the Selection of Patients With Lung Cancer for Treatment With Targeted Tyrosine Kinase Inhibitors: American Society of Clinical Oncology Endorsement of the College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology Clinical Practice Guideline Update

  Journal of Clinical Oncology · 2018 · 10.1200/jco.2017.76.7293

• CNS Response to Osimertinib Versus Standard Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients With Untreated EGFR -Mutated Advanced Non–Small-Cell Lung Cancer

  Journal of Clinical Oncology · 2018 · 10.1200/jco.2018.78.3118

• Sensitive tumour detection and classification using plasma cell-free DNA methylomes

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0703-0

• Brigatinib in Patients With Crizotinib-Refractory Anaplastic Lymphoma Kinase–Positive Non–Small-Cell Lung Cancer: A Randomized, Multicenter Phase II Trial

  Journal of Clinical Oncology · 2017 · 10.1200/jco.2016.71.5904

• Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

  Nature Genetics · 2017 · https://doi.org/10.1038/ng.3892

• Systemic Therapy for Stage IV Non–Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update

  Journal of Clinical Oncology · 2017 · 10.1200/jco.2017.74.6065

• Perceptions of palliative care among patients with advanced cancer and their caregivers

  Canadian Medical Association Journal · 2016 · https://doi.org/10.1503/cmaj.151171

• Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial

  Genome Medicine · 2016 · https://doi.org/10.1186/s13073-016-0364-2

• The impact of brain metastasis on quality of life, resource utilization and survival in patients with non-small-cell lung cancer

  Cancer Treatment Reviews · 2016 · 10.1016/j.ctrv.2016.03.009

• Recommendations for the Use of WBC Growth Factors: American Society of Clinical Oncology Clinical Practice Guideline Update

  Journal of Clinical Oncology · 2015 · 10.1200/jco.2015.62.3488

• Symptomatic Toxicities Experienced During Anticancer Treatment: Agreement Between Patient and Physician Reporting in Three Randomized Trials

  Journal of Clinical Oncology · 2015 · https://doi.org/10.1200/jco.2014.57.9334

• Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer

  New England Journal of Medicine · 2015 · 10.1056/nejmoa1501824

• Early palliative care for patients with advanced cancer: a cluster-randomised controlled trial

  The Lancet · 2014 · https://doi.org/10.1016/s0140-6736(13)62416-2

• Molecular Testing for Selection of Patients With Lung Cancer for Epidermal Growth Factor Receptor and Anaplastic Lymphoma Kinase Tyrosine Kinase Inhibitors: American Society of Clinical Oncology Endorsement of the College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology Guideline

  Journal of Clinical Oncology · 2014 · 10.1200/jco.2014.57.3055

• Phase III Trial of Cisplatin Plus Gemcitabine With Either Placebo or Bevacizumab As First-Line Therapy for Nonsquamous Non–Small-Cell Lung Cancer: AVAiL

  Journal of Clinical Oncology · 2009 · 10.1200/jco.2007.14.5466

• Trimodality Therapy With Induction Chemotherapy Followed by Extrapleural Pneumonectomy and Adjuvant High-Dose Hemithoracic Radiation for Malignant Pleural Mesothelioma

  Journal of Clinical Oncology · 2009 · 10.1200/jco.2008.17.5604

• Age and Comorbidity As Independent Prognostic Factors in the Treatment of Non–Small-Cell Lung Cancer: A Review of National Cancer Institute of Canada Clinical Trials Group Trials

  Journal of Clinical Oncology · 2007 · 10.1200/jco.2007.12.8322

• Communicating With Realism and Hope: Incurable Cancer Patients' Views on the Disclosure of Prognosis

  Journal of Clinical Oncology · 2005 · https://doi.org/10.1200/jco.2005.11.138

• Platinum-Based Versus Non-Platinum-Based Chemotherapy in Advanced Non-Small-Cell Lung Cancer: A Meta-Analysis of the Published Literature

  Journal of Clinical Oncology · 2005 · 10.1200/jco.2005.03.045

• Cancer Patient Preferences for Communication of Prognosis in the Metastatic Setting

  Journal of Clinical Oncology · 2004 · https://doi.org/10.1200/jco.2004.04.095

Current projects

No projects listed.