N.C.J. Strynadka

Research interests

Publications

• An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity

  Nature Communications · 2023 · 10.1038/s41467-023-37029-3

• Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site

  Nature Communications · 2020 · 10.1038/s41467-020-19662-4

• Assembly, structure, function and regulation of type III secretion systems

  Nature Reviews Microbiology · 2017 · https://doi.org/10.1038/nrmicro.2017.20

• Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance

  Nature · 2014 · https://doi.org/10.1038/nature13445

• New Delhi Metallo-β-Lactamase: Structural Insights into β-Lactam Recognition and Inhibition

  Journal of the American Chemical Society · 2012 · 10.1021/ja303579d

• Structural Perspective of Peptidoglycan Biosynthesis and Assembly

  Annual Review of Biochemistry · 2012 · 10.1146/annurev-biochem-061809-112742

• Crystal structure of New Delhi metallo‐β‐lactamase reveals molecular basis for antibiotic resistance

  Protein Science · 2011 · 10.1002/pro.697

• Studies of a Ring-Cleaving Dioxygenase Illuminate the Role of Cholesterol Metabolism in the Pathogenesis of Mycobacterium tuberculosis

  PLoS Pathogens · 2009 · 10.1371/journal.ppat.1000344

• A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system

  Nature Structural & Molecular Biology · 2009 · 10.1038/nsmb.1603

• Structural Insight into the Transglycosylation Step of Bacterial Cell-Wall Biosynthesis

  Science · 2007 · 10.1126/science.1136611

• High-throughput screening methodology for the directed evolution of glycosyltransferases

  Nature Methods · 2006 · 10.1038/nmeth899

• β-Lactam antibiotic resistance: a current structural perspective

  Current Opinion in Microbiology · 2005 · 10.1016/j.mib.2005.08.016

• Structural characterization of the molecular platform for type III secretion system assembly

  Nature · 2005 · 10.1038/nature03554

• Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog

  Nature Structural & Molecular Biology · 2004 · 10.1038/nsmb720

• Insights into the respiratory electron transfer pathway from the structure of nitrate reductase A

  Nature Structural & Molecular Biology · 2003 · https://doi.org/10.1038/nsb969

• Structural basis for the β lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus

  Nature Structural Biology · 2002 · 10.1038/nsb858

• Signal Peptidases

  Chemical Reviews · 2002 · 10.1021/cr010166y

• Crystal Structure of LexA

  Cell · 2001 · 10.1016/s0092-8674(01)00479-2

• Crystal structure of the retaining galactosyltransferase LgtC from Neisseria meningitidis in complex with donor and acceptor sugar analogs.

  Nature Structural Biology · 2001 · https://doi.org/10.1038/84168

• Crystal structure of enteropathogenic Escherichia coli intimin–receptor complex

  Nature · 2000 · 10.1038/35016618

• Crystal structure of a bacterial signal peptidase in complex with a β-lactam inhibitor

  Nature · 1998 · 10.1038/24196

• Molecular structure of the acyl-enzyme intermediate in β-lactam hydrolysis at 1.7 Å resolution

  Nature · 1992 · https://doi.org/10.1038/359700a0

• Lysozyme revisited: Crystallographic evidence for distortion of an N-acetylmuramic acid residue bound in site D

  Journal of Molecular Biology · 1991 · 10.1016/0022-2836(91)90021-w

• Calcium-Binding Sites in Proteins: A Structural Perspective

  Advances in protein chemistry · 1991 · 10.1016/s0065-3233(08)60535-5

• CRYSTAL STRUCTURES OF THE HELIX-LOOP-HELIX CALCIUM-BINDING PROTEINS

  Annual Review of Biochemistry · 1989 · https://doi.org/10.1146/annurev.bi.58.070189.004511

Current projects

No projects listed.