Irene L. Andrulis

Research interests

Publications

• Pathology of Tumors Associated With Pathogenic Germline Variants in 9 Breast Cancer Susceptibility Genes

  JAMA Oncology · 2022 · https://doi.org/10.1001/jamaoncol.2021.6744

• Genetic insights into biological mechanisms governing human ovarian ageing

  Nature · 2021 · https://doi.org/10.1038/s41586-021-03779-7

• Cancer Risks Associated With BRCA1 and BRCA2 Pathogenic Variants.

  Kölner Universitäts PublikationsServer (Universität zu Köln) · 2021 · https://doi.org/10.17863/cam.78454

• Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-019-0537-1

• Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-020-0609-2

• Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

  The American Journal of Human Genetics · 2018 · https://doi.org/10.1016/j.ajhg.2018.11.002

• A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer

  Nature Genetics · 2018 · https://doi.org/10.1038/s41588-018-0132-x

• Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

  Nature Genetics · 2017 · https://doi.org/10.1038/ng.3826

• Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

  Nature Genetics · 2017 · https://doi.org/10.1038/ng.3841

• Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

  Nature Genetics · 2017 · https://doi.org/10.1038/ng.3785

• Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers

  JAMA · 2017 · https://doi.org/10.1001/jama.2017.7112

• RAD51B in Familial Breast Cancer

  PLoS ONE · 2016 · https://doi.org/10.1371/journal.pone.0153788

• Age- and Tumor Subtype–Specific Breast Cancer Risk Estimates for CH EK 2 *1100delC Carriers

  Journal of Clinical Oncology · 2016 · https://doi.org/10.1200/jco.2016.66.5844

• Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types

  JNCI Journal of the National Cancer Institute · 2015 · https://doi.org/10.1093/jnci/djv279

• Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

  Nature Genetics · 2015 · https://doi.org/10.1038/ng.3412

• MicroRNA Related Polymorphisms and Breast Cancer Risk

  PLoS ONE · 2014 · https://doi.org/10.1371/journal.pone.0109973

• Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

  Nature · 2014 · https://doi.org/10.1038/nature13545

• Genome-wide association studies identify four ER negative–specific breast cancer risk loci

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2561

• Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

  PLoS Genetics · 2013 · https://doi.org/10.1371/journal.pgen.1003212

• Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2566

• Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1 / 2 (CIMBA)

  Cancer Epidemiology Biomarkers & Prevention · 2012 · https://doi.org/10.1158/1055-9965.epi-11-0775

• Rare variants in the ATMgene and risk of breast cancer

  Breast Cancer Research · 2011 · https://doi.org/10.1186/bcr2919

• Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium

  Human Molecular Genetics · 2011 · https://doi.org/10.1093/hmg/ddr228

• Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction

  Cancer Research · 2010 · https://doi.org/10.1158/0008-5472.can-10-1907

• Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies

  JNCI Journal of the National Cancer Institute · 2010 · https://doi.org/10.1093/jnci/djq526

• A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population

  Nature Genetics · 2010 · https://doi.org/10.1038/ng.669

• Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

  The American Journal of Human Genetics · 2008 · https://doi.org/10.1016/j.ajhg.2008.02.008

• RAD51 135G→C Modifies Breast Cancer Risk among BRCA2 Mutation Carriers: Results from a Combined Analysis of 19 Studies

  The American Journal of Human Genetics · 2007 · https://doi.org/10.1086/522611

Current projects

No projects listed.