Paul M. O’Byrne

Research interests

Publications

• Inhaled Combined Budesonide–Formoterol as Needed in Mild Asthma

  New England Journal of Medicine · 2018 · 10.1056/nejmoa1715274

• As-Needed Budesonide–Formoterol versus Maintenance Budesonide in Mild Asthma

  New England Journal of Medicine · 2018 · 10.1056/nejmoa1715275

• A summary of the new GINA strategy: a roadmap to asthma control

  European Respiratory Journal · 2015 · 10.1183/13993003.00853-2015

• Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial

  The Lancet Respiratory Medicine · 2015 · https://doi.org/10.1016/s2213-2600(15)00197-6

• Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia

  Journal of Allergy and Clinical Immunology · 2015 · 10.1016/j.jaci.2015.05.037

• Effects of an Anti-TSLP Antibody on Allergen-Induced Asthmatic Responses

  New England Journal of Medicine · 2014 · 10.1056/nejmoa1402895

• Uniform definition of asthma severity, control, and exacerbations: Document presented for the World Health Organization Consultation on Severe Asthma

  Journal of Allergy and Clinical Immunology · 2010 · https://doi.org/10.1016/j.jaci.2010.07.019

• Circulating Fibrocytes Are an Indicator of Poor Prognosis in Idiopathic Pulmonary Fibrosis

  American Journal of Respiratory and Critical Care Medicine · 2009 · 10.1164/rccm.200810-1534oc

• Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia

  New England Journal of Medicine · 2009 · https://doi.org/10.1056/nejmoa0805435

• An Official American Thoracic Society/European Respiratory Society Statement: Asthma Control and Exacerbations

  American Journal of Respiratory and Critical Care Medicine · 2009 · https://doi.org/10.1164/rccm.200801-060st

• Severe Exacerbations and Decline in Lung Function in Asthma

  American Journal of Respiratory and Critical Care Medicine · 2008 · 10.1164/rccm.200807-1126oc

• A new perspective on concepts of asthma severity and control

  European Respiratory Journal · 2008 · https://doi.org/10.1183/09031936.00155307

• Global strategy for asthma management and prevention: GINA executive summary

  European Respiratory Journal · 2007 · https://doi.org/10.1183/09031936.00138707

• Budesonide/Formoterol Combination Therapy as Both Maintenance and Reliever Medication in Asthma

  American Journal of Respiratory and Critical Care Medicine · 2004 · 10.1164/rccm.200407-884oc

• Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial

  The Lancet · 2003 · 10.1016/s0140-6736(03)12891-7

• Low Dose Inhaled Budesonide and Formoterol in Mild Persistent Asthma

  American Journal of Respiratory and Critical Care Medicine · 2001 · 10.1164/ajrccm.164.8.2104102

• Development and validation of a questionnaire to measure asthma control

  European Respiratory Journal · 1999 · https://doi.org/10.1034/j.1399-3003.1999.14d29.x

• Treatment of Asthma with Drugs Modifying the Leukotriene Pathway

  New England Journal of Medicine · 1999 · 10.1056/nejm199901213400306

• Managing Cough as a Defense Mechanism and as a Symptom

  CHEST Journal · 1998 · 10.1378/chest.114.2_supplement.133s

• Effect of Inhaled Formoterol and Budesonide on Exacerbations of Asthma

  New England Journal of Medicine · 1997 · https://doi.org/10.1056/nejm199711133372001

• A comparison of the efficacy and safety of inhaled corticosteroids in asthma

  Allergy · 1997 · https://doi.org/10.1111/j.1398-9995.1997.tb05047.x

• Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults

  European Respiratory Journal · 1993 · 10.1183/09041950.053s1693

• Inhibition of Exercise-Induced Bronchoconstriction by MK-571, a Potent Leukotriene D4–Receptor Antagonist

  New England Journal of Medicine · 1990 · 10.1056/nejm199012203232504

• Effect of Long-term Treatment with an Inhaled Corticosteroid (Budesonide) on Airway Hyperresponsiveness and Clinical Asthma in Nonsteroid-dependent Asthmatics

  American Review of Respiratory Disease · 1990 · 10.1164/ajrccm/142.4.832

• Late Asthmatic Responses

  American Review of Respiratory Disease · 1987 · 10.1164/ajrccm/136.3.740

• Bronchoalveolar Cell Profiles of Asthmatic and Nonasthmatic Subjects

  American Review of Respiratory Disease · 1987 · 10.1164/ajrccm/136.2.379

• Importance of airway inflammation for hyperresponsiveness induced by ozone.

  PubMed · 1983 · https://doi.org/10.1164/arrd.1983.127.6.686

• Bronchial responsiveness to histamine or methacholine in asthma: measurement and clinical significance

  Journal of Allergy and Clinical Immunology · 1981 · 10.1016/0091-6749(81)90132-9

Current projects

No projects listed.