Jens Meiler

Research interests

Publications

• Modeling conformational states of proteins with AlphaFold

  Current Opinion in Structural Biology · 2023 · 10.1016/j.sbi.2023.102645

• Sampling alternative conformational states of transporters and receptors with AlphaFold2

  eLife · 2022 · 10.7554/elife.75751

• Potently neutralizing and protective human antibodies against SARS-CoV-2

  Nature · 2020 · https://doi.org/10.1038/s41586-020-2548-6

• Macromolecular modeling and design in Rosetta: recent methods and frameworks

  Nature Methods · 2020 · https://doi.org/10.1038/s41592-020-0848-2

• Protocols for Molecular Modeling with Rosetta3 and RosettaScripts

  Biochemistry · 2016 · 10.1021/acs.biochem.6b00444

• Outcome of the First wwPDB Hybrid/Integrative Methods Task Force Workshop

  Structure · 2015 · 10.1016/j.str.2015.05.013

• Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator

  Science · 2014 · 10.1126/science.1249489

• Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders

  Nature Reviews Drug Discovery · 2014 · 10.1038/nrd4308

• Computational Methods in Drug Discovery

  Pharmacological Reviews · 2013 · https://doi.org/10.1124/pr.112.007336

• Small-molecule ligand docking into comparative models with Rosetta

  Nature Protocols · 2013 · 10.1038/nprot.2013.074

• RosettaScripts: A Scripting Language Interface to the Rosetta Macromolecular Modeling Suite

  PLoS ONE · 2011 · 10.1371/journal.pone.0020161

• Rosetta Ligand Docking with Flexible XML Protocols

  Methods in molecular biology · 2011 · 10.1007/978-1-61779-465-0_10

• Practically Useful: What the R osetta Protein Modeling Suite Can Do for You

  Biochemistry · 2010 · 10.1021/bi902153g

• Rosetta3

  Methods in enzymology on CD-ROM/Methods in enzymology · 2010 · https://doi.org/10.1016/b978-0-12-381270-4.00019-6

• Solvent accessible surface area approximations for rapid and accurate protein structure prediction

  Journal of Molecular Modeling · 2009 · 10.1007/s00894-009-0454-9

• Structure of KCNE1 and Implications for How It Modulates the KCNQ1 Potassium Channel

  Biochemistry · 2008 · 10.1021/bi800875q

• Recognition Dynamics Up to Microseconds Revealed from an RDC-Derived Ubiquitin Ensemble in Solution

  Science · 2008 · https://doi.org/10.1126/science.1157092

• ROSETTALIGAND: Protein–small molecule docking with full side‐chain flexibility

  Proteins Structure Function and Bioinformatics · 2006 · 10.1002/prot.21086

• New algorithms and an in silico benchmark for computational enzyme design

  Protein Science · 2006 · 10.1110/ps.062353106

• PROSHIFT: Protein chemical shift prediction using artificial neural networks

  Journal of Biomolecular NMR · 2003 · 10.1023/a:1023060720156

• Rosetta predictions in CASP5: Successes, failures, and prospects for complete automation

  Proteins Structure Function and Bioinformatics · 2003 · 10.1002/prot.10552

• Coupled prediction of protein secondary and tertiary structure

  Proceedings of the National Academy of Sciences · 2003 · 10.1073/pnas.1831973100

• Model-Free Analysis of Protein Backbone Motion from Residual Dipolar Couplings

  Journal of the American Chemical Society · 2002 · 10.1021/ja011883c

• Model-Free Approach to the Dynamic Interpretation of Residual Dipolar Couplings in Globular Proteins

  Journal of the American Chemical Society · 2001 · 10.1021/ja010002z

• Generation and evaluation of dimension-reduced amino acid parameter representations by artificial neural networks

  Journal of Molecular Modeling · 2001 · 10.1007/s008940100038

Current projects

No projects listed.