Peter B. Dirks

Research interests

Publications

• Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity

  Nature Cancer · 2021 · https://doi.org/10.1038/s43018-020-00154-9

• GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-020-18020-8

• Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas

  Cancer Cell · 2020 · https://doi.org/10.1016/j.ccell.2020.03.011

• Childhood cerebellar tumours mirror conserved fetal transcriptional programs

  Nature · 2019 · https://doi.org/10.1038/s41586-019-1158-7

• Stalled developmental programs at the root of pediatric brain tumors

  Nature Genetics · 2019 · https://doi.org/10.1038/s41588-019-0531-7

• A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression

  Neuron · 2018 · https://doi.org/10.1016/j.neuron.2018.09.046

• DNA hypermethylation within TERT promoter upregulates TERT expression in cancer

  Journal of Clinical Investigation · 2018 · https://doi.org/10.1172/jci121303

• Intertumoral Heterogeneity within Medulloblastoma Subgroups

  Cancer Cell · 2017 · https://doi.org/10.1016/j.ccell.2017.05.005

• Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

  Nature · 2017 · https://doi.org/10.1038/nature23666

• Comprehensive Analysis of Hypermutation in Human Cancer

  Cell · 2017 · https://doi.org/10.1016/j.cell.2017.09.048

• Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas

  Journal of Clinical Oncology · 2017 · https://doi.org/10.1200/jco.2016.71.8726

• Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency

  Journal of Clinical Oncology · 2016 · https://doi.org/10.1200/jco.2016.66.6552

• BRAF Mutation and CDKN2A Deletion Define a Clinically Distinct Subgroup of Childhood Secondary High-Grade Glioma

  Journal of Clinical Oncology · 2015 · https://doi.org/10.1200/jco.2014.58.3922

• Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

  Nature Genetics · 2015 · https://doi.org/10.1038/ng.3202

• High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

  Cell · 2015 · https://doi.org/10.1016/j.cell.2015.11.015

• Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma

  Cancer Cell · 2014 · https://doi.org/10.1016/j.ccr.2014.05.005

• Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

  Nature · 2014 · https://doi.org/10.1038/nature13108

• Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study

  The Lancet Oncology · 2013 · https://doi.org/10.1016/s1470-2045(13)70110-4

• Subgroup-specific structural variation across 1,000 medulloblastoma genomes

  Nature · 2012 · https://doi.org/10.1038/nature11327

• Cancer Stem Cells—Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem Cells

  Cancer Research · 2006 · https://doi.org/10.1158/0008-5472.can-06-3126

• Identification of human brain tumour initiating cells

  Nature · 2004 · https://doi.org/10.1038/nature03128

• Identification of a cancer stem cell in human brain tumors.

  PubMed · 2003

Current projects

No projects listed.