Sriram Subramaniam

Research interests

Publications

• SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex

  Science · 2022 · https://doi.org/10.1126/science.abn7760

• Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation

  Nature Chemical Biology · 2022 · https://doi.org/10.1038/s41589-022-01059-7

• Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies

  PLoS Biology · 2021 · https://doi.org/10.1371/journal.pbio.3001237

• Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases

  Science · 2019 · https://doi.org/10.1126/science.aay0543

• Cryo-EM structure of human rhodopsin bound to an inhibitory G protein

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0215-y

• Power Grid Protection of the Muscle Mitochondrial Reticulum

  Cell Reports · 2017 · https://doi.org/10.1016/j.celrep.2017.03.063

• Cryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex

  Cell · 2017 · https://doi.org/10.1016/j.cell.2017.09.006

• Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery

  Cell · 2016 · https://doi.org/10.1016/j.cell.2016.05.040

• 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition

  Science · 2016 · https://doi.org/10.1126/science.aad7974

• Focused ion beams in biology

  Nature Methods · 2015 · https://doi.org/10.1038/nmeth.3623

• 2.2 Å resolution cryo-EM structure of β-galactosidase in complex with a cell-permeant inhibitor

  Science · 2015 · https://doi.org/10.1126/science.aab1576

• Mitochondrial reticulum for cellular energy distribution in muscle

  Nature · 2015 · https://doi.org/10.1038/nature14614

• Structure of β-galactosidase at 3.2-Å resolution obtained by cryo-electron microscopy

  Proceedings of the National Academy of Sciences · 2014 · https://doi.org/10.1073/pnas.1402809111

• Structural mechanism of glutamate receptor activation and desensitization

  Nature · 2014 · https://doi.org/10.1038/nature13603

• A collaborative framework for 3D alignment and classification of heterogeneous subvolumes in cryo-electron tomography

  Journal of Structural Biology · 2012 · https://doi.org/10.1016/j.jsb.2012.10.010

• Cryo‐electron microscopy – a primer for the non‐microscopist

  FEBS Journal · 2012 · https://doi.org/10.1111/febs.12078

• Structural Mechanism of Trimeric HIV-1 Envelope Glycoprotein Activation

  PLoS Pathogens · 2012 · https://doi.org/10.1371/journal.ppat.1002797

• Molecular architecture of native HIV-1 gp120 trimers

  Nature · 2008 · https://doi.org/10.1038/nature07159

• Electron Tomography of the Contact between T Cells and SIV/HIV-1: Implications for Viral Entry

  PLoS Pathogens · 2007 · https://doi.org/10.1371/journal.ppat.0030063

• Site-specific 3D imaging of cells and tissues with a dual beam microscope

  Journal of Structural Biology · 2006 · https://doi.org/10.1016/j.jsb.2006.03.006

• Three-dimensional structure of a bacterial oxalate transporter

  Nature Structural Biology · 2002 · https://doi.org/10.1038/nsb821

• Molecular mechanism of vectorial proton translocation by bacteriorhodopsin

  Nature · 2000 · https://doi.org/10.1038/35020614

• Protein conformational changes in the bacteriorhodopsin photocycle 1 1Edited by B. Honig

  Journal of Molecular Biology · 1999 · https://doi.org/10.1006/jmbi.1999.2589

• Analytical shape computation of macromolecules: II. Inaccessible cavities in proteins.

  PubMed · 1998

• Electron diffraction analysis of structural changes in the photocycle of bacteriorhodopsin.

  The EMBO Journal · 1993 · https://doi.org/10.1002/j.1460-2075.1993.tb05625.x

Current projects

No projects listed.