Michael W. Parker

Research interests

Publications

• Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0387-5

• Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites

  Nature Communications · 2017 · 10.1038/ncomms14188

• A Systematic and Functional Classification of Streptococcus pyogenes That Serves as a New Tool for Molecular Typing and Vaccine Development

  The Journal of Infectious Diseases · 2014 · 10.1093/infdis/jiu260

• Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor

  Science · 2014 · https://doi.org/10.1126/science.1249783

• Oncogenic protein interfaces: small molecules, big challenges

  Nature reviews. Cancer · 2014 · 10.1038/nrc3690

• The GM – CSF / IL‐3 / IL‐5 cytokine receptor family: from ligand recognition to initiation of signaling

  Immunological Reviews · 2012 · 10.1111/j.1600-065x.2012.01164.x

• Zanamivir-Resistant Influenza Viruses with a Novel Neuraminidase Mutation

  Journal of Virology · 2009 · 10.1128/jvi.01200-09

• The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

  Blood · 2009 · 10.1182/blood-2008-12-164004

• The Structure of the GM-CSF Receptor Complex Reveals a Distinct Mode of Cytokine Receptor Activation

  Cell · 2008 · 10.1016/j.cell.2008.05.053

• Model for growth hormone receptor activation based on subunit rotation within a receptor dimer

  Nature Structural & Molecular Biology · 2005 · 10.1038/nsmb977

• Pore-forming protein toxins: from structure to function

  Progress in Biophysics and Molecular Biology · 2004 · https://doi.org/10.1016/j.pbiomolbio.2004.01.009

• Structure of the Alzheimer's Disease Amyloid Precursor Protein Copper Binding Domain

  Journal of Biological Chemistry · 2003 · 10.1074/jbc.m300629200

• AMPK β Subunit Targets Metabolic Stress Sensing to Glycogen

  Current Biology · 2003 · 10.1016/s0960-9822(03)00292-6

• Rowe and Kahn's Model of Successful Aging Revisited

  The Gerontologist · 2002 · https://doi.org/10.1093/geront/42.5.613

• The Mechanism of Membrane Insertion for a Cholesterol-Dependent Cytolysin

  Cell · 1999 · 10.1016/s0092-8674(00)81660-8

• Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein.

  Nature Structural Biology · 1999 · 10.1038/7562

• Identification of a Membrane-Spanning Domain of the Thiol-Activated Pore-Forming Toxin Clostridium perfringens Perfringolysin O: An α-Helical to β-Sheet Transition Identified by Fluorescence Spectroscopy

  Biochemistry · 1998 · 10.1021/bi981452f

• Structure of a Cholesterol-Binding, Thiol-Activated Cytolysin and a Model of Its Membrane Form

  Cell · 1997 · https://doi.org/10.1016/s0092-8674(00)80251-2

• Crystal structure of a theta‐class glutathione transferase.

  The EMBO Journal · 1995 · 10.1002/j.1460-2075.1995.tb07207.x

• Structure and function of glutathione S-transferases

  Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · 1994 · https://doi.org/10.1016/0167-4838(94)90086-8

• Structure of the Aeromonas toxin proaerolysin in its water-soluble and membrane-channel states

  Nature · 1994 · 10.1038/367292a0

• Refined structure of the pore-forming domain of colicin A at 2.4 Å resolution

  Journal of Molecular Biology · 1992 · 10.1016/0022-2836(92)90550-4

• Three-dimensional structure of class π glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8 Å resolution

  Journal of Molecular Biology · 1992 · 10.1016/0022-2836(92)90692-d

• Structure of the membrane-pore-forming fragment of colicin A

  Nature · 1989 · 10.1038/337093a0

• Iron‐ and manganese‐containing superoxide dismutases can be distinguished by analysis of their primary structures

  FEBS Letters · 1988 · 10.1016/0014-5793(88)81160-8

Current projects

No projects listed.