Ladan Fazli

Research interests

Publications

• Plasma ctDNA is a tumor tissue surrogate and enables clinical-genomic stratification of metastatic bladder cancer

  Nature Communications · 2021 · https://doi.org/10.1038/s41467-020-20493-6

• An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer

  Nature Cell Biology · 2021 · https://doi.org/10.1038/s41556-021-00743-5

• IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling

  Nature Communications · 2019 · 10.1038/s41467-018-08152-3

• ONECUT2 is a driver of neuroendocrine prostate cancer

  Nature Communications · 2019 · https://doi.org/10.1038/s41467-018-08133-6

• Circulating Tumor DNA Abundance and Potential Utility in De Novo Metastatic Prostate Cancer

  European Urology · 2019 · https://doi.org/10.1016/j.eururo.2018.12.042

• Automatic grading of prostate cancer in digitized histopathology images: Learning from multiple experts

  Medical Image Analysis · 2018 · 10.1016/j.media.2018.09.005

• The Master Neural Transcription Factor BRN2 Is an Androgen Receptor–Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer

  Cancer Discovery · 2016 · https://doi.org/10.1158/2159-8290.cd-15-1263

• Targeting ASCT2 ‐mediated glutamine uptake blocks prostate cancer growth and tumour development

  The Journal of Pathology · 2015 · 10.1002/path.4518

• Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein

  Cancer Cell · 2015 · 10.1016/j.ccell.2015.09.003

• The Placental Gene PEG10 Promotes Progression of Neuroendocrine Prostate Cancer

  Cell Reports · 2015 · https://doi.org/10.1016/j.celrep.2015.07.012

• High Fidelity Patient-Derived Xenografts for Accelerating Prostate Cancer Discovery and Drug Development

  Cancer Research · 2013 · https://doi.org/10.1158/0008-5472.can-13-2921-t

• Hsp27 Regulates Epithelial Mesenchymal Transition, Metastasis, and Circulating Tumor Cells in Prostate Cancer

  Cancer Research · 2013 · 10.1158/0008-5472.can-12-3979

• Targeting Amino Acid Transport in Metastatic Castration-Resistant Prostate Cancer: Effects on Cell Cycle, Cell Growth, and Tumor Development

  JNCI Journal of the National Cancer Institute · 2013 · 10.1093/jnci/djt241

• From sequence to molecular pathology, and a mechanism driving the neuroendocrine phenotype in prostate cancer

  The Journal of Pathology · 2012 · https://doi.org/10.1002/path.4047

• The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis

  The EMBO Journal · 2011 · 10.1038/emboj.2011.158

• Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance

  Nature Medicine · 2010 · https://doi.org/10.1038/nm.2236

• Insulin receptor expression by human prostate cancers

  The Prostate · 2008 · 10.1002/pros.20852

• Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer

  BMC Cancer · 2008 · 10.1186/1471-2407-8-230

• Frequency of the TMPRSS2:ERG gene fusion is increased in moderate to poorly differentiated prostate cancers

  Journal of Clinical Pathology · 2007 · 10.1136/jcp.2006.043810

• Intraprostatic Androgens and Androgen-Regulated Gene Expression Persist after Testosterone Suppression: Therapeutic Implications for Castration-Resistant Prostate Cancer

  Cancer Research · 2007 · 10.1158/0008-5472.can-06-3332

• Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development

  Proceedings of the National Academy of Sciences · 2007 · https://doi.org/10.1073/pnas.0703942104

• Cooperative Interactions between Androgen Receptor (AR) and Heat-Shock Protein 27 Facilitate AR Transcriptional Activity

  Cancer Research · 2007 · 10.1158/0008-5472.can-07-2057

• A Phase I Pharmacokinetic and Pharmacodynamic Study of OGX-011, a 2′-Methoxyethyl Antisense Oligonucleotide to Clusterin, in Patients With Localized Prostate Cancer

  JNCI Journal of the National Cancer Institute · 2005 · 10.1093/jnci/dji252

• Increased Hsp27 after Androgen Ablation Facilitates Androgen-Independent Progression in Prostate Cancer via Signal Transducers and Activators of Transcription 3–Mediated Suppression of Apoptosis

  Cancer Research · 2005 · 10.1158/0008-5472.can-05-1840

• Heat Shock Protein 27 Increases after Androgen Ablation and Plays a Cytoprotective Role in Hormone-Refractory Prostate Cancer

  Cancer Research · 2004 · 10.1158/0008-5472.can-03-3998

• Regulation of tumor angiogenesis by integrin-linked kinase (ILK)

  Cancer Cell · 2004 · 10.1016/s1535-6108(03)00281-2

Current projects

No projects listed.