Mark A. Wainberg

Research interests

Publications

• Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study

  The Lancet HIV · 2017 · https://doi.org/10.1016/s2352-3018(17)30089-9

• Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study

  The Lancet HIV · 2017 · https://doi.org/10.1016/s2352-3018(17)30089-9

• CRISPR/Cas9-Derived Mutations Both Inhibit HIV-1 Replication and Accelerate Viral Escape

  Cell Reports · 2016 · 10.1016/j.celrep.2016.03.042

• On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection

  New England Journal of Medicine · 2015 · https://doi.org/10.1056/nejmoa1506273

• The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA

  Retrovirology · 2015 · 10.1186/s12977-015-0150-z

• Characterization of the R263K Mutation in HIV-1 Integrase That Confers Low-Level Resistance to the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir

  Journal of Virology · 2011 · 10.1128/jvi.06591-11

• Development of Antiretroviral Drug Resistance

  New England Journal of Medicine · 2011 · 10.1056/nejmra1004180

• RIG-I-Mediated Antiviral Signaling Is Inhibited in HIV-1 Infection by a Protease-Mediated Sequestration of RIG-I

  Journal of Virology · 2010 · 10.1128/jvi.01635-10

• High Rates of Forward Transmission Events after Acute/Early HIV‐1 Infection

  The Journal of Infectious Diseases · 2007 · 10.1086/512088

• HIV-1 subtype C viruses rapidly develop K65R resistance to tenofovir in cell culture

  AIDS · 2006 · 10.1097/01.aids.0000232228.88511.0b

• Methylation of Tat by PRMT6 Regulates Human Immunodeficiency Virus Type 1 Gene Expression

  Journal of Virology · 2004 · 10.1128/jvi.79.1.124-131.2005

• A V106M mutation in HIV-1 clade C viruses exposed to efavirenz confers cross-resistance to non-nucleoside reverse transcriptase inhibitors

  AIDS · 2003 · 10.1097/00002030-200301030-00001

• Persistence and Fitness of Multidrug-Resistant Human Immunodeficiency Virus Type 1 Acquired in Primary Infection

  Journal of Virology · 2002 · 10.1128/jvi.76.4.1753-1761.2002

• Prevalence of HIV-1 resistant to antiretroviral drugs in 81 individuals newly infected by sexual contact or injecting drug use

  AIDS · 2000 · 10.1097/00002030-200001280-00003

• In vitro Selection and Characterization of HIV-1 with Reduced Susceptibility to PMPA

  Antiviral Therapy · 1999 · 10.1177/135965359900400205

• Public Health Implications of Antiretroviral Therapy and HIV Drug Resistance

  JAMA · 1998 · 10.1001/jama.279.24.1977

• A Randomized, Double-blind Trial Comparing Combinations of Nevirapine, Didanosine, and Zidovudine for HIV-Infected Patients

  JAMA · 1998 · 10.1001/jama.279.12.930

• Suppression of plasma viral load below 20 copies/ml is required to achieve a long-term response to therapy

  AIDS · 1998 · 10.1097/00002030-199813000-00008

• Enhanced Fidelity of 3TC-Selected Mutant HIV-1 Reverse Transcriptase

  Science · 1996 · 10.1126/science.271.5253.1282

• Role of Pr160gag-pol in mediating the selective incorporation of tRNA(Lys) into human immunodeficiency virus type 1 particles

  Journal of Virology · 1994 · 10.1128/jvi.68.4.2065-2072.1994

• Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine

  Antimicrobial Agents and Chemotherapy · 1994 · 10.1128/aac.38.2.275

• The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine

  Antimicrobial Agents and Chemotherapy · 1993 · 10.1128/aac.37.6.1390

• High-level resistance to (-) enantiomeric 2'-deoxy-3'-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase

  Antimicrobial Agents and Chemotherapy · 1993 · 10.1128/aac.37.10.2231

• Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine

  Journal of Virology · 1992 · 10.1128/jvi.66.12.7128-7135.1992

• Anti-human immunodeficiency virus type 1 activity and in vitro toxicity of 2'-deoxy-3'-thiacytidine (BCH-189), a novel heterocyclic nucleoside analog

  Antimicrobial Agents and Chemotherapy · 1991 · 10.1128/aac.35.7.1386

Current projects

No projects listed.