David Malkin

Research interests

Publications

• The TP53 Database: transition from the International Agency for Research on Cancer to the US National Cancer Institute

  Cell Death and Differentiation · 2022 · https://doi.org/10.1038/s41418-022-00976-3

• Medulloblastoma

  Nature Reviews Disease Primers · 2019 · https://doi.org/10.1038/s41572-019-0063-6

• Childhood cerebellar tumours mirror conserved fetal transcriptional programs

  Nature · 2019 · https://doi.org/10.1038/s41586-019-1158-7

• Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort

  The Lancet Oncology · 2018 · https://doi.org/10.1016/s1470-2045(18)30242-0

• Comprehensive Analysis of Hypermutation in Human Cancer

  Cell · 2017 · https://doi.org/10.1016/j.cell.2017.09.048

• Cancer Screening Recommendations for Individuals with Li-Fraumeni Syndrome

  Clinical Cancer Research · 2017 · https://doi.org/10.1158/1078-0432.ccr-17-0408

• Baseline Surveillance in Li-Fraumeni Syndrome Using Whole-Body Magnetic Resonance Imaging

  JAMA Oncology · 2017 · https://doi.org/10.1001/jamaoncol.2017.1968

• Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency

  Journal of Clinical Oncology · 2016 · https://doi.org/10.1200/jco.2016.66.6552

• Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors

  Cancer Cell · 2016 · https://doi.org/10.1016/j.ccell.2016.11.003

• BRAF Mutation and CDKN2A Deletion Define a Clinically Distinct Subgroup of Childhood Secondary High-Grade Glioma

  Journal of Clinical Oncology · 2015 · https://doi.org/10.1200/jco.2014.58.3922

• Cytogenetic Prognostication Within Medulloblastoma Subgroups

  Journal of Clinical Oncology · 2014 · https://doi.org/10.1200/jco.2013.50.9539

• Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

  Nature · 2014 · https://doi.org/10.1038/nature13108

• Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma

  Cancer Cell · 2014 · https://doi.org/10.1016/j.ccr.2014.05.005

• Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study

  The Lancet Oncology · 2013 · https://doi.org/10.1016/s1470-2045(13)70110-4

• Subgroup-Specific Prognostic Implications of TP53 Mutation in Medulloblastoma

  Journal of Clinical Oncology · 2013 · https://doi.org/10.1200/jco.2012.48.5052

• Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

  Nature · 2012 · https://doi.org/10.1038/nature10833

• Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

  Cell · 2012 · https://doi.org/10.1016/j.cell.2011.12.013

• Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples

  Acta Neuropathologica · 2011 · https://doi.org/10.1007/s00401-011-0899-7

• TP53 Alterations Determine Clinical Subgroups and Survival of Patients With Choroid Plexus Tumors

  Journal of Clinical Oncology · 2010 · https://doi.org/10.1200/jco.2009.26.8169

• Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

  Science · 1990 · https://doi.org/10.1126/science.1978757

Current projects

No projects listed.