MacDonald J. Christie

Research interests

Publications

• Morphine‐induced respiratory depression is independent of β‐arrestin2 signalling

  British Journal of Pharmacology · 2020 · https://doi.org/10.1111/bph.15004

• Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists

  Science Signaling · 2020 · https://doi.org/10.1126/scisignal.aaz3140

• Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects

  Nature Communications · 2019 · https://doi.org/10.1038/s41467-018-08162-1

• Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

  Science Translational Medicine · 2017 · https://doi.org/10.1126/scitranslmed.aal3447

• Regulation of µ-Opioid Receptors: Desensitization, Phosphorylation, Internalization, and Tolerance

  Pharmacological Reviews · 2013 · https://doi.org/10.1124/pr.112.005942

• Conus Venom Peptide Pharmacology

  Pharmacological Reviews · 2012 · https://doi.org/10.1124/pr.111.005322

• Analysis of opioid efficacy, tolerance, addiction and dependence from cell culture to human

  British Journal of Pharmacology · 2011 · https://doi.org/10.1111/j.1476-5381.2011.01335.x

• Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

  Cell · 2010 · https://doi.org/10.1016/j.cell.2010.06.036

• Cellular neuroadaptations to chronic opioids: tolerance, withdrawal and addiction

  British Journal of Pharmacology · 2008 · https://doi.org/10.1038/bjp.2008.100

• Gingerols: a novel class of vanilloid receptor (VR1) agonists

  British Journal of Pharmacology · 2002 · https://doi.org/10.1038/sj.bjp.0704925

• Cellular and Synaptic Adaptations Mediating Opioid Dependence

  Physiological Reviews · 2001 · https://doi.org/10.1152/physrev.2001.81.1.299

• Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bridge

  Nature Structural Biology · 2000 · https://doi.org/10.1038/75921

• Actions of Cannabinoids on Membrane Properties and Synaptic Transmission in Rat Periaqueductal Gray Neurons In Vitro

  Molecular Pharmacology · 2000 · https://doi.org/10.1016/s0026-895x(24)23200-4

• OPIOID RECEPTOR SIGNALLING MECHANISMS

  Clinical and Experimental Pharmacology and Physiology · 1999 · https://doi.org/10.1046/j.1440-1681.1999.03049.x

• Presynaptic inhibitory action of opioids on synaptic transmission in the rat periaqueductal grey in vitro.

  The Journal of Physiology · 1997 · https://doi.org/10.1113/jphysiol.1997.sp021872

• How opioids inhibit GABA-mediated neurotransmission

  Nature · 1997 · https://doi.org/10.1038/37610

• Nociceptin receptor coupling to a potassium conductance in rat locus coeruleus neurones in vitro

  British Journal of Pharmacology · 1996 · https://doi.org/10.1111/j.1476-5381.1996.tb16080.x

• Increase by the ORL1 receptor (opioid receptor‐like1) ligand, nociceptin, of inwardly rectifying K conductance in dorsal raphe nucleus neurones

  British Journal of Pharmacology · 1996 · https://doi.org/10.1111/j.1476-5381.1996.tb15329.x

• Heteropolymeric potassium channels expressed in xenopus oocytes from cloned subunits

  Neuron · 1990 · https://doi.org/10.1016/0896-6273(90)90052-h

• Expression of a Cloned Rat Brain Potassium Channel in Xenopus Oocytes

  Science · 1989 · https://doi.org/10.1126/science.2539643

• Cloning and expression of a rat D2 dopamine receptor cDNA

  Nature · 1988 · https://doi.org/10.1038/336783a0

• Cellular mechanisms of opioid tolerance: studies in single brain neurons.

  Molecular Pharmacology · 1987 · https://doi.org/10.1016/s0026-895x(25)13048-4

• Excitatory amino acid projections to the nucleus accumbens septi in the rat: A retrograde transport study utilizingd[3H]aspartate and [3H]GABA

  Neuroscience · 1987 · https://doi.org/10.1016/0306-4522(87)90345-9

• Mu and delta receptors belong to a family of receptors that are coupled to potassium channels.

  Proceedings of the National Academy of Sciences · 1987 · https://doi.org/10.1073/pnas.84.15.5487

• Excitotoxin lesions suggest an aspartatergic projection from rat medial prefrontal cortex to ventral tegmental area

  Brain Research · 1985 · https://doi.org/10.1016/0006-8993(85)90140-4

Current projects

No projects listed.