Arthur Christopoulos

Research interests

Publications

• The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

  British Journal of Pharmacology · 2023 · https://doi.org/10.1111/bph.16177

• THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

  British Journal of Pharmacology · 2021 · https://doi.org/10.1111/bph.15538

• THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

  British Journal of Pharmacology · 2019 · 10.1111/bph.14748

• THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Introduction and Other Protein Targets

  British Journal of Pharmacology · 2019 · 10.1111/bph.14747

• Mechanisms of signalling and biased agonism in G protein-coupled receptors

  Nature Reviews Molecular Cell Biology · 2018 · https://doi.org/10.1038/s41580-018-0049-3

• Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

  Nature · 2017 · 10.1038/nature22327

• THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein‐coupled receptors

  British Journal of Pharmacology · 2017 · 10.1111/bph.13878

• Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

  Nature · 2016 · 10.1038/nature17188

• Muscarinic acetylcholine receptors: novel opportunities for drug development

  Nature Reviews Drug Discovery · 2014 · 10.1038/nrd4295

• Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs

  Nature · 2013 · 10.1038/nature12595

• Emerging paradigms in GPCR allostery: implications for drug discovery

  Nature Reviews Drug Discovery · 2013 · https://doi.org/10.1038/nrd4052

• Activation and allosteric modulation of a muscarinic acetylcholine receptor

  Nature · 2013 · https://doi.org/10.1038/nature12735

• Signalling bias in new drug discovery: detection, quantification and therapeutic impact

  Nature Reviews Drug Discovery · 2012 · 10.1038/nrd3954

• A Simple Method for Quantifying Functional Selectivity and Agonist Bias

  ACS Chemical Neuroscience · 2011 · 10.1021/cn200111m

• Neuropsychopharmacology

  Journal · 2010 · https://doi.org/10.1007/978-3-540-68706-1_4410

• Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

  Nature Reviews Drug Discovery · 2008 · 10.1038/nrd2760

• Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology

  Trends in Pharmacological Sciences · 2007 · 10.1016/j.tips.2007.06.004

• Allosteric Modulation of G Protein–Coupled Receptors

  The Annual Review of Pharmacology and Toxicology · 2006 · https://doi.org/10.1146/annurev.pharmtox.47.120505.105159

• Functional Selectivity and Classical Concepts of Quantitative Pharmacology

  Journal of Pharmacology and Experimental Therapeutics · 2006 · https://doi.org/10.1124/jpet.106.104463

• G-Protein–Coupled Receptor Mas Is a Physiological Antagonist of the Angiotensin II Type 1 Receptor

  Circulation · 2005 · https://doi.org/10.1161/01.cir.0000160867.23556.7d

• Allosteric Modulation of the Cannabinoid CB1 Receptor

  Molecular Pharmacology · 2005 · 10.1124/mol.105.016162

• Fitting Models to Biological Data Using Linear and Nonlinear Regression

  · 2004 · 10.1093/oso/9780195171792.001.0001

• Fitting models to biological data using linear and nonlinear regression : a practical guide to curve fitting

  · 2004

• International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on Terms and Symbols in Quantitative Pharmacology

  Pharmacological Reviews · 2003 · 10.1124/pr.55.4.4

• G Protein-Coupled Receptor Allosterism and Complexing

  Pharmacological Reviews · 2002 · 10.1124/pr.54.2.323

• Allosteric binding sites on cell-surface receptors: novel targets for drug discovery

  Nature Reviews Drug Discovery · 2002 · 10.1038/nrd746

Current projects

No projects listed.