Terence J. O’Brien

Research interests

Publications

• Add-on Cannabidiol Treatment for Drug-Resistant Seizures in Tuberous Sclerosis Complex

  JAMA Neurology · 2020 · 10.1001/jamaneurol.2020.4607

• White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA-Epilepsy study

  Brain · 2020 · 10.1093/brain/awaa200

• Motor neuroprosthesis implanted with neurointerventional surgery improves capacity for activities of daily living tasks in severe paralysis: first in-human experience

  Journal of NeuroInterventional Surgery · 2020 · 10.1136/neurintsurg-2020-016862

• Ultra-Rare Genetic Variation in the Epilepsies: A Whole-Exome Sequencing Study of 17,606 Individuals

  The American Journal of Human Genetics · 2019 · https://doi.org/10.1016/j.ajhg.2019.05.020

• Epilepsy in adults

  The Lancet · 2019 · https://doi.org/10.1016/s0140-6736(18)32596-0

• Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-07524-z

• Epilepsy

  Nature Reviews Disease Primers · 2018 · https://doi.org/10.1038/nrdp.2018.24

• Inflammation in epileptogenesis after traumatic brain injury

  Journal of Neuroinflammation · 2017 · 10.1186/s12974-016-0786-1

• Ultra-rare genetic variation in common epilepsies: a case-control sequencing study

  The Lancet Neurology · 2017 · 10.1016/s1474-4422(16)30359-3

• Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study

  Brain · 2017 · https://doi.org/10.1093/brain/awx341

• Epileptic Seizure Prediction Using Big Data and Deep Learning: Toward a Mobile System

  EBioMedicine · 2017 · https://doi.org/10.1016/j.ebiom.2017.11.032

• Minimally invasive endovascular stent-electrode array for high-fidelity, chronic recordings of cortical neural activity

  Nature Biotechnology · 2016 · https://doi.org/10.1038/nbt.3428

• Interictal spikes and epileptic seizures: their relationship and underlying rhythmicity

  Brain · 2016 · https://doi.org/10.1093/brain/aww019

• Perampanel for tonic-clonic seizures in idiopathic generalized epilepsy

  Neurology · 2015 · 10.1212/wnl.0000000000001930

• Prediction of seizure likelihood with a long-term, implanted seizure advisory system in patients with drug-resistant epilepsy: a first-in-man study

  The Lancet Neurology · 2013 · https://doi.org/10.1016/s1474-4422(13)70075-9

• Mutations in DEPDC5 cause familial focal epilepsy with variable foci

  Nature Genetics · 2013 · 10.1038/ng.2599

• T-Type Calcium Channel Blockers That Attenuate Thalamic Burst Firing and Suppress Absence Seizures

  Science Translational Medicine · 2012 · 10.1126/scitranslmed.3003120

• Identification of new epilepsy treatments: Issues in preclinical methodology

  Epilepsia · 2012 · 10.1111/j.1528-1167.2011.03391.x

• Randomized phase III study 306

  Neurology · 2012 · https://doi.org/10.1212/wnl.0b013e318254473a

• Neuropsychiatric symptomatology predicts seizure recurrence in newly treated patients

  Neurology · 2010 · 10.1212/wnl.0b013e3181f25b16

• NMDA Receptor Hypofunction Leads to Generalized and Persistent Aberrant γ Oscillations Independent of Hyperlocomotion and the State of Consciousness

  PLoS ONE · 2009 · 10.1371/journal.pone.0006755

• MRI-negative PET-positive temporal lobe epilepsy: a distinct surgically remediable syndrome

  Brain · 2004 · https://doi.org/10.1093/brain/awh257

• Subtraction peri-ictal SPECT is predictive of extratemporal epilepsy surgery outcome

  Neurology · 2000 · 10.1212/wnl.55.11.1668

• Subtraction ictal SPECT co‐registered to MRI improves clinical usefulness of SPECT in localizing the surgical seizure focus

  Neurology · 1998 · https://doi.org/10.1212/wnl.50.2.445

• Mechanisms whereby Propofol Mediates Peripheral Vasolidation in Humans

  Anesthesiology · 1997 · https://doi.org/10.1097/00000542-199701000-00010

Current projects

No projects listed.