Jinghui Zhang

Research interests

Publications

• Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor

  Cell Genomics · 2022 · https://doi.org/10.1016/j.xgen.2022.100179

• The genomic landscape of pediatric acute lymphoblastic leukemia

  Nature Genetics · 2022 · https://doi.org/10.1038/s41588-022-01159-z

• Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia

  Cancer Discovery · 2021 · https://doi.org/10.1158/2159-8290.cd-21-0145

• PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia

  Nature Genetics · 2019 · https://doi.org/10.1038/s41588-018-0315-5

• Analysis of error profiles in deep next-generation sequencing data

  Genome biology · 2019 · https://doi.org/10.1186/s13059-019-1659-6

• Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia

  Blood · 2019 · https://doi.org/10.1182/blood.2019002220

• The landscape of genomic alterations across childhood cancers

  Nature · 2018 · https://doi.org/10.1038/nature25480

• Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-06485-7

• The genetic basis and cell of origin of mixed phenotype acute leukaemia

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0436-0

• Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours

  Nature · 2018 · https://doi.org/10.1038/nature25795

• Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort

  The Lancet Oncology · 2018 · https://doi.org/10.1016/s1470-2045(18)30242-0

• High Frequency and Poor Outcome of Philadelphia Chromosome–Like Acute Lymphoblastic Leukemia in Adults

  Journal of Clinical Oncology · 2017 · https://doi.org/10.1200/jco.2016.69.0073

• The whole-genome landscape of medulloblastoma subtypes

  Nature · 2017 · https://doi.org/10.1038/nature22973

• Pediatric non–Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes

  Nature Genetics · 2017 · https://doi.org/10.1038/ng.3772

• Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia

  EBioMedicine · 2016 · https://doi.org/10.1016/j.ebiom.2016.04.038

• Deregulation of DUX4 and ERG in acute lymphoblastic leukemia

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3691

• Germline Mutations in Predisposition Genes in Pediatric Cancer

  New England Journal of Medicine · 2015 · 10.1056/nejmoa1508054

• Exploring genomic alteration in pediatric cancer using ProteinPaint

  Nature Genetics · 2015 · https://doi.org/10.1038/ng.3466

• Germline genetic variation in ETV6 and risk of childhood acute lymphoblastic leukaemia: a systematic genetic study

  The Lancet Oncology · 2015 · https://doi.org/10.1016/s1470-2045(15)00369-1

• Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia

  New England Journal of Medicine · 2014 · 10.1056/nejmoa1403088

• Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations

  Cancer Discovery · 2014 · https://doi.org/10.1158/2159-8290.cd-14-0622

• Outcomes of Children With BCR-ABL1 –Like Acute Lymphoblastic Leukemia Treated With Risk-Directed Therapy Based on the Levels of Minimal Residual Disease

  Journal of Clinical Oncology · 2014 · https://doi.org/10.1200/jco.2014.55.4105

• C11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma

  Nature · 2014 · 10.1038/nature13109

• The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma

  Nature Genetics · 2014 · https://doi.org/10.1038/ng.2938

• Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma

  Cell Reports · 2014 · 10.1016/j.celrep.2014.03.003

• A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2754

• Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas

  Nature Genetics · 2013 · 10.1038/ng.2611

• The genomic landscape of hypodiploid acute lymphoblastic leukemia

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2532

• Novel mutations target distinct subgroups of medulloblastoma

  Nature · 2012 · https://doi.org/10.1038/nature11213

• Genetic Alterations Activating Kinase and Cytokine Receptor Signaling in High-Risk Acute Lymphoblastic Leukemia

  Cancer Cell · 2012 · https://doi.org/10.1016/j.ccr.2012.06.005

• The Pediatric Cancer Genome Project

  Nature Genetics · 2012 · https://doi.org/10.1038/ng.2287

• The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

  Nature · 2012 · https://doi.org/10.1038/nature10725

• Deletion of IKZF1 and Prognosis in Acute Lymphoblastic Leukemia

  New England Journal of Medicine · 2009 · https://doi.org/10.1056/nejmoa0808253

• Genome-wide association study identifies novel breast cancer susceptibility loci

  Nature · 2007 · https://doi.org/10.1038/nature05887

• The Sequence of the Human Genome

  Science · 2001 · https://doi.org/10.1126/science.1058040

Current projects

No projects listed.