Andrew K. Godwin

Research interests

Publications

• Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.06.013

• Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-020-0609-2

• Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip

  Nature Biomedical Engineering · 2019 · 10.1038/s41551-019-0356-9

• The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

  Cell Reports · 2018 · 10.1016/j.celrep.2018.03.075

• Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

  Cell · 2018 · 10.1016/j.cell.2018.03.034

• A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

  Cancer Cell · 2018 · 10.1016/j.ccell.2018.03.014

• The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

  Cell Reports · 2018 · 10.1016/j.celrep.2018.06.032

• A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations

  Cancer Cell · 2017 · 10.1016/j.ccell.2017.04.013

• Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores

  Journal of Clinical Oncology · 2017 · https://doi.org/10.1200/jco.2016.69.4935

• Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma

  Cell Reports · 2016 · 10.1016/j.celrep.2016.02.024

• The Molecular Taxonomy of Primary Prostate Cancer

  Cell · 2015 · 10.1016/j.cell.2015.10.025

• Identification of six new susceptibility loci for invasive epithelial ovarian cancer

  Nature Genetics · 2015 · https://doi.org/10.1038/ng.3185

• Association of Type and Location ofBRCA1andBRCA2Mutations With Risk of Breast and Ovarian Cancer

  JAMA · 2015 · https://doi.org/10.1001/jama.2014.5985

• Inherited Mutations in 17 Breast Cancer Susceptibility Genes Among a Large Triple-Negative Breast Cancer Cohort Unselected for Family History of Breast Cancer

  Journal of Clinical Oncology · 2014 · 10.1200/jco.2014.57.1414

• DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

  PLoS Genetics · 2014 · https://doi.org/10.1371/journal.pgen.1004256

• Integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology

  Lab on a Chip · 2014 · 10.1039/c4lc00662c

• Genome-wide association studies identify four ER negative–specific breast cancer risk loci

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2561

• Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

  PLoS Genetics · 2013 · https://doi.org/10.1371/journal.pgen.1003212

• Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1 / 2 (CIMBA)

  Cancer Epidemiology Biomarkers & Prevention · 2012 · https://doi.org/10.1158/1055-9965.epi-11-0775

• Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes

  Nature Genetics · 2012 · 10.1038/ng.2455

• Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2

  Breast Cancer Research · 2011 · https://doi.org/10.1186/bcr3052

• A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer

  Nature Genetics · 2011 · https://doi.org/10.1038/ng.985

• Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer

  PLoS Biology · 2011 · https://doi.org/10.1371/journal.pbio.1001199

• Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction

  Cancer Research · 2010 · https://doi.org/10.1158/0008-5472.can-10-1907

• A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24

  Nature Genetics · 2010 · https://doi.org/10.1038/ng.668

• Standard Operating Procedures for Serum and Plasma Collection: Early Detection Research Network Consensus Statement Standard Operating Procedure Integration Working Group

  Journal of Proteome Research · 2008 · 10.1021/pr800545q

• Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

  The American Journal of Human Genetics · 2008 · https://doi.org/10.1016/j.ajhg.2008.02.008

• Expression of Epiregulin and Amphiregulin and K-ras Mutation Status Predict Disease Control in Metastatic Colorectal Cancer Patients Treated With Cetuximab

  Journal of Clinical Oncology · 2007 · 10.1200/jco.2006.10.5437

• MicroRNA-34b and MicroRNA-34c Are Targets of p53 and Cooperate in Control of Cell Proliferation and Adhesion-Independent Growth

  Cancer Research · 2007 · 10.1158/0008-5472.can-07-1585

• RAD51 135G→C Modifies Breast Cancer Risk among BRCA2 Mutation Carriers: Results from a Combined Analysis of 19 Studies

  The American Journal of Human Genetics · 2007 · https://doi.org/10.1086/522611

• AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth

  Oncogene · 2004 · 10.1038/sj.onc.1207721

• A Grb2-associated docking protein in EGF- and insulin-receptor signalling

  Nature · 1996 · 10.1038/379560a0

• Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors.

  PubMed · 1995

• AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

  Proceedings of the National Academy of Sciences · 1992 · 10.1073/pnas.89.19.9267

• High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.

  Proceedings of the National Academy of Sciences · 1992 · 10.1073/pnas.89.7.3070

Current projects

No projects listed.