Catriona McLean

Research interests

Publications

• Transcriptional signature in microglia associated with Aβ plaque phagocytosis

  Nature Communications · 2021 · https://doi.org/10.1038/s41467-021-23111-1

• TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.09.020

• cIMPACT-NOW update 5: recommended grading criteria and terminologies for IDH-mutant astrocytomas

  Acta Neuropathologica · 2020 · https://doi.org/10.1007/s00401-020-02127-9

• A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

  Nature Neuroscience · 2019 · https://doi.org/10.1038/s41593-019-0539-4

• Congenital Titinopathy: Comprehensive characterization and pathogenic insights

  Annals of Neurology · 2018 · https://doi.org/10.1002/ana.25241

• Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

  Cell · 2018 · https://doi.org/10.1016/j.cell.2018.09.053

• Multisite study of the relationships between antemortem [ 11 C]PIB‐PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology

  Alzheimer s & Dementia · 2018 · https://doi.org/10.1016/j.jalz.2018.09.001

• Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML

  Cell stem cell · 2017 · https://doi.org/10.1016/j.stem.2017.11.006

• A rigorous method to enrich for exosomes from brain tissue

  Journal of Extracellular Vesicles · 2017 · https://doi.org/10.1080/20013078.2017.1348885

• PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS

  Journal of Medical Genetics · 2016 · https://doi.org/10.1136/jmedgenet-2016-103839

• Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent

  PLoS Medicine · 2016 · https://doi.org/10.1371/journal.pmed.1002105

• Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

  Cancer Discovery · 2016 · https://doi.org/10.1158/2159-8290.cd-15-1227

• Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy

  Nature Communications · 2015 · https://doi.org/10.1038/ncomms8247

• Identification of Novel Genetic Markers of Breast Cancer Survival

  JNCI Journal of the National Cancer Institute · 2015 · https://doi.org/10.1093/jnci/djv081

• Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy

  Acta Neuropathologica · 2015 · https://doi.org/10.1007/s00401-015-1509-x

• TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions

  Acta Neuropathologica · 2014 · https://doi.org/10.1007/s00401-013-1239-x

• Histological validation of cardiac magnetic resonance analysis of regional and diffuse interstitial myocardial fibrosis

  European Heart Journal - Cardiovascular Imaging · 2014 · https://doi.org/10.1093/ehjci/jeu182

• Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

  Nature Medicine · 2012 · https://doi.org/10.1038/nm.2613

• Mutations in the N-terminal Actin-Binding Domain of Filamin C Cause a Distal Myopathy

  The American Journal of Human Genetics · 2011 · https://doi.org/10.1016/j.ajhg.2011.04.021

• Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium

  Human Molecular Genetics · 2011 · https://doi.org/10.1093/hmg/ddr228

• 18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

  Brain · 2011 · https://doi.org/10.1093/brain/awr038

• Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies

  JNCI Journal of the National Cancer Institute · 2010 · https://doi.org/10.1093/jnci/djq526

• Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 Studies

  PLoS Medicine · 2010 · https://doi.org/10.1371/journal.pmed.1000279

• Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

  Nature Genetics · 2010 · 10.1038/ng.536

• Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

  Cell · 2010 · https://doi.org/10.1016/j.cell.2010.08.014

• BCL2 in breast cancer: a favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received

  British Journal of Cancer · 2010 · https://doi.org/10.1038/sj.bjc.6605736

• Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers

  Proceedings of the National Academy of Sciences · 2010 · https://doi.org/10.1073/pnas.1015245107

• In Situ Detection of Inflammatory Mediators in Post Mortem Human Brain Tissue after Traumatic Injury

  Journal of Neurotrauma · 2009 · https://doi.org/10.1089/neu.2009.1120

• RETRACTED: Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

  Neurobiology of Disease · 2008 · https://doi.org/10.1016/j.nbd.2008.02.009

• Cerebral radiation necrosis: Incidence, outcomes, and risk factors with emphasis on radiation parameters and chemotherapy

  International Journal of Radiation Oncology*Biology*Physics · 2006 · https://doi.org/10.1016/j.ijrobp.2005.12.002

• Increased expression of the amyloid precursor β‐secretase in Alzheimer's disease

  Annals of Neurology · 2002 · https://doi.org/10.1002/ana.10208

• Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

  Neuron · 2001 · https://doi.org/10.1016/s0896-6273(01)00317-8

• Aqueous Dissolution of Alzheimer's Disease Aβ Amyloid Deposits by Biometal Depletion

  Journal of Biological Chemistry · 1999 · https://doi.org/10.1074/jbc.274.33.23223

• Soluble pool of A? amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

  Annals of Neurology · 1999 · https://doi.org/10.1002/1531-8249(199912)46:6<860::aid-ana8>3.0.co;2-m

Current projects

No projects listed.