Daniel D. Buchanan

Research interests

Publications

• Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

  Nature Genetics · 2022 · https://doi.org/10.1038/s41588-022-01222-9

• Characteristics of Early-Onset vs Late-Onset Colorectal Cancer

  JAMA Surgery · 2021 · https://doi.org/10.1001/jamasurg.2021.2380

• Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

  BMC Medicine · 2020 · https://doi.org/10.1186/s12916-020-01855-9

• Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk

  The American Journal of Human Genetics · 2020 · https://doi.org/10.1016/j.ajhg.2020.07.006

• Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-020-14389-8

• Shared heritability and functional enrichment across six solid cancers

  Nature Communications · 2019 · https://doi.org/10.1038/s41467-018-08054-4

• Association analyses identify 31 new risk loci for colorectal cancer susceptibility

  Nature Communications · 2019 · https://doi.org/10.1038/s41467-019-09775-w

• Cumulative Burden of Colorectal Cancer–Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer

  Gastroenterology · 2019 · https://doi.org/10.1053/j.gastro.2019.12.012

• Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses

  Gastroenterology · 2019 · https://doi.org/10.1053/j.gastro.2019.12.020

• Novel Common Genetic Susceptibility Loci for Colorectal Cancer

  JNCI Journal of the National Cancer Institute · 2018 · https://doi.org/10.1093/jnci/djy099

• Cancer Risks for PMS2 -Associated Lynch Syndrome

  Journal of Clinical Oncology · 2018 · https://doi.org/10.1200/jco.2018.78.4777

• Identification of nine new susceptibility loci for endometrial cancer

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-05427-7

• Discovery of common and rare genetic risk variants for colorectal cancer

  Nature Genetics · 2018 · https://doi.org/10.1038/s41588-018-0286-6

• Determining Risk of Colorectal Cancer and Starting Age of Screening Based on Lifestyle, Environmental, and Genetic Factors

  Gastroenterology · 2018 · https://doi.org/10.1053/j.gastro.2018.02.021

• Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations

  Cancer Research · 2016 · https://doi.org/10.1158/0008-5472.can-15-2980

• Prevalence and Penetrance of Major Genes and Polygenes for Colorectal Cancer

  Cancer Epidemiology Biomarkers & Prevention · 2016 · https://doi.org/10.1158/1055-9965.epi-16-0693

• Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer

  Cancer Research · 2014 · https://doi.org/10.1158/0008-5472.can-14-0013

• Tumor Mismatch Repair Immunohistochemistry and DNA MLH1 Methylation Testing of Patients With Endometrial Cancer Diagnosed at Age Younger Than 60 Years Optimizes Triage for Population-Level Germline Mismatch Repair Gene Mutation Testing

  Journal of Clinical Oncology · 2013 · https://doi.org/10.1200/jco.2013.51.2129

• Correlation of tumour BRAF mutations and MLH1 methylation with germline mismatch repair (MMR) gene mutation status: a literature review assessing utility of tumour features for MMR variant classification

  Journal of Medical Genetics · 2012 · https://doi.org/10.1136/jmedgenet-2011-100714

• Identification of Lynch Syndrome Among Patients With Colorectal Cancer

  JAMA · 2012 · https://doi.org/10.1001/jama.2012.13088

• Risks of Lynch Syndrome Cancers for MSH6 Mutation Carriers

  JNCI Journal of the National Cancer Institute · 2009 · https://doi.org/10.1093/jnci/djp473

• CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

  Nature Genetics · 2006 · https://doi.org/10.1038/ng1834

Current projects

No projects listed.