Richard J. Simpson

Research interests

Publications

• Extracellular vesicles in cancer — implications for future improvements in cancer care

  Nature Reviews Clinical Oncology · 2018 · 10.1038/s41571-018-0036-9

• Extracellular vesicle isolation and characterization: toward clinical application

  Journal of Clinical Investigation · 2016 · 10.1172/jci81129

• A Protocol for Exosome Isolation and Characterization: Evaluation of Ultracentrifugation, Density-Gradient Separation, and Immunoaffinity Capture Methods

  Methods in molecular biology · 2015 · 10.1007/978-1-4939-2550-6_15

• Exosomes and their roles in immune regulation and cancer

  Seminars in Cell and Developmental Biology · 2015 · 10.1016/j.semcdb.2015.02.009

• FunRich: An open access standalone functional enrichment and interaction network analysis tool

  PROTEOMICS · 2015 · 10.1002/pmic.201400515

• Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma

  PROTEOMICS · 2013 · 10.1002/pmic.201300282

• Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes

  Methods · 2012 · https://doi.org/10.1016/j.ymeth.2012.01.002

• Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

  PLoS Biology · 2012 · 10.1371/journal.pbio.1001450

• ExoCarta 2012: database of exosomal proteins, RNA and lipids

  Nucleic Acids Research · 2011 · 10.1093/nar/gkr828

• Exosomes: Extracellular organelles important in intercellular communication

  Journal of Proteomics · 2010 · 10.1016/j.jprot.2010.06.006

• Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

  Proceedings of the National Academy of Sciences · 2010 · 10.1073/pnas.0911409107

• ExoCarta: A compendium of exosomal proteins and RNA

  PROTEOMICS · 2009 · 10.1002/pmic.200900351

• Exosomes: proteomic insights and diagnostic potential

  Expert Review of Proteomics · 2009 · 10.1586/epr.09.17

• Proteomics Analysis of A33 Immunoaffinity-purified Exosomes Released from the Human Colon Tumor Cell Line LIM1215 Reveals a Tissue-specific Protein Signature

  Molecular & Cellular Proteomics · 2009 · 10.1074/mcp.m900152-mcp200

• Proteomic profiling of exosomes: Current perspectives

  PROTEOMICS · 2008 · 10.1002/pmic.200800109

• An evaluation, comparison, and accurate benchmarking of several publicly available MS/MS search algorithms: Sensitivity and specificity analysis

  PROTEOMICS · 2005 · https://doi.org/10.1002/pmic.200500126

• Overview of the HUPO Plasma Proteome Project: Results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly‐available database

  PROTEOMICS · 2005 · https://doi.org/10.1002/pmic.200500358

• A common open representation of mass spectrometry data and its application to proteomics research

  Nature Biotechnology · 2004 · 10.1038/nbt1031

• HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins

  Journal of Biological Chemistry · 2002 · 10.1074/jbc.m109891200

• Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

  Cell · 2000 · 10.1016/s0092-8674(00)00009-x

• The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

  Proceedings of the National Academy of Sciences · 1999 · 10.1073/pnas.96.5.2071

• Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H).

  Proceedings of the National Academy of Sciences · 1990 · 10.1073/pnas.87.11.4120

• Style self-incompatibility gene products of Nicotlana alata are ribonucleases

  Nature · 1989 · 10.1038/342955a0

• Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.

  The Journal of Experimental Medicine · 1987 · 10.1084/jem.165.3.914

• Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF).

  The EMBO Journal · 1987 · 10.1002/j.1460-2075.1987.tb02742.x

• Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.

  Proceedings of the National Academy of Sciences · 1986 · 10.1073/pnas.83.24.9679

Current projects

No projects listed.