Trevor W. Hambley

Research interests

Publications

• Harnessing the properties of cobalt coordination complexes for biological application

  Coordination Chemistry Reviews · 2017 · https://doi.org/10.1016/j.ccr.2017.11.027

• Mechanisms of cell uptake and toxicity of the anticancer drug cisplatin

  Metallomics · 2014 · https://doi.org/10.1039/c4mt00238e

• Delivery and release of curcumin by a hypoxia-activated cobalt chaperone: a XANES and FLIM study

  Chemical Science · 2013 · https://doi.org/10.1039/c3sc51530c

• Pt( iv ) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate

  Chemical Communications · 2011 · https://doi.org/10.1039/c1cc16647f

• Platinum Drug Distribution in Cancer Cells and Tumors

  Chemical Reviews · 2009 · https://doi.org/10.1021/cr9001066

• Is Anticancer Drug Development Heading in the Right Direction?

  Cancer Research · 2009 · https://doi.org/10.1158/0008-5472.can-08-3786

• Bioreductive activation and drug chaperoning in cobalt pharmaceuticals

  Dalton Transactions · 2007 · https://doi.org/10.1039/b707121c

• Basis for Design and Development of Platinum(IV) Anticancer Complexes

  Journal of Medicinal Chemistry · 2007 · https://doi.org/10.1021/jm070280u

• Metal-Based Therapeutics

  Science · 2007 · https://doi.org/10.1126/science.1150504

• Developing new metal-based therapeutics: challenges and opportunities

  Dalton Transactions · 2007 · https://doi.org/10.1039/b706075k

• Studies of a Cobalt( III ) Complex of the MMP Inhibitor Marimastat: A Potential Hypoxia‐Activated Prodrug

  Chemistry - A European Journal · 2006 · https://doi.org/10.1002/chem.200601137

• The Discovery and Development of Cisplatin

  Journal of Chemical Education · 2006 · https://doi.org/10.1021/ed083p728

• The cellular distribution and oxidation state of platinum(II) and platinum(IV) antitumour complexes in cancer cells

  JBIC Journal of Biological Inorganic Chemistry · 2003 · https://doi.org/10.1007/s00775-003-0471-6

• Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized

  Coordination Chemistry Reviews · 2002 · https://doi.org/10.1016/s0010-8545(02)00086-3

• Platinum(IV) antitumour compounds: their bioinorganic chemistry

  Coordination Chemistry Reviews · 2002 · https://doi.org/10.1016/s0010-8545(02)00026-7

• Platinum binding to DNA: structural controls and consequences

  Journal of the Chemical Society Dalton Transactions · 2001 · https://doi.org/10.1039/b105406f

• Slowing of Cisplatin Aquation in the Presence of DNA but Not in the Presence of Phosphate: Improved Understanding of Sequence Selectivity and the Roles of Monoaquated and Diaquated Species in the Binding of Cisplatin to DNA

  Inorganic Chemistry · 2000 · https://doi.org/10.1021/ic000847w

• Syntheses and Characterization of Anti-inflammatory Dinuclear and Mononuclear Zinc Indomethacin Complexes. Crystal Structures of [Zn2(Indomethacin)4(L)2] (L = N,N-Dimethylacetamide, Pyridine, 1-Methyl-2-pyrrolidinone) and [Zn(Indomethacin)2(L1)2] (L1 = Ethanol, Methanol)

  Inorganic Chemistry · 2000 · https://doi.org/10.1021/ic991477i

• Relationships between hydrophobicity, reactivity, accumulation and peripheral nerve toxicity of a series of platinum drugs

  British Journal of Cancer · 2000 · https://doi.org/10.1054/bjoc.1999.1026

• Molecular Modeling of Inorganic Compounds

  Journal · 2000 · https://doi.org/10.1002/9783527612987

• Part I. Theory

  Journal · 2000 · https://doi.org/10.1002/9783527612987.part1

• A 1H NMR Study of the DNA Binding of Ruthenium(II) Polypyridyl Complexes

  Inorganic Chemistry · 1998 · https://doi.org/10.1021/ic971194v

• The influence of structure on the activity and toxicity of Pt anti-cancer drugs

  Coordination Chemistry Reviews · 1997 · https://doi.org/10.1016/s0010-8545(97)00023-4

• The Influence of the Axial Ligands of a Series of Platinum(IV) Anti-Cancer Complexes on Their Reduction to Platinum(II) and Reaction With DNA

  Australian Journal of Chemistry · 1995 · https://doi.org/10.1071/ch9950793

• Metal ion encapsulation: cobalt cages derived from polyamines, formaldehyde, and nitromethane

  Journal of the American Chemical Society · 1984 · https://doi.org/10.1021/ja00331a016

Current projects

No projects listed.