Ricky W. Johnstone

Research interests

Publications

• Targeting the epigenetic regulation of antitumour immunity

  Nature Reviews Drug Discovery · 2020 · https://doi.org/10.1038/s41573-020-0077-5

• Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-07551-w

• Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0387-5

• BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

  Cell Reports · 2017 · https://doi.org/10.1016/j.celrep.2017.02.011

• BET inhibitor resistance emerges from leukaemia stem cells

  Nature · 2015 · https://doi.org/10.1038/nature14888

• Activation of HIV Transcription with Short-Course Vorinostat in HIV-Infected Patients on Suppressive Antiretroviral Therapy

  PLoS Pathogens · 2014 · https://doi.org/10.1371/journal.ppat.1004473

• New and emerging HDAC inhibitors for cancer treatment

  Journal of Clinical Investigation · 2014 · https://doi.org/10.1172/jci69738

• Response of BRAF -Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis

  Cancer Discovery · 2014 · https://doi.org/10.1158/2159-8290.cd-13-0440

• Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

  Nature Reviews Drug Discovery · 2014 · https://doi.org/10.1038/nrd4360

• Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

  Cancer Cell · 2012 · https://doi.org/10.1016/j.ccr.2012.05.019

• Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

  Immunity · 2012 · https://doi.org/10.1016/j.immuni.2012.02.014

• Epigenetics in cancer: Targeting chromatin modifications

  Molecular Cancer Therapeutics · 2009 · https://doi.org/10.1158/1535-7163.mct-08-0860

• The TRAIL apoptotic pathway in cancer onset, progression and therapy

  Nature reviews. Cancer · 2008 · https://doi.org/10.1038/nrc2465

• Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

  Proceedings of the National Academy of Sciences · 2007 · https://doi.org/10.1073/pnas.0709443104

• Anticancer activities of histone deacetylase inhibitors

  Nature Reviews Drug Discovery · 2006 · https://doi.org/10.1038/nrd2133

• Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors

  Proceedings of the National Academy of Sciences · 2005 · https://doi.org/10.1073/pnas.0500369102

• Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

  Nature Reviews Drug Discovery · 2002 · https://doi.org/10.1038/nrd772

• Apoptosis

  Cell · 2002 · https://doi.org/10.1016/s0092-8674(02)00625-6

• The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

  Proceedings of the National Academy of Sciences · 2001 · https://doi.org/10.1073/pnas.191208598

Current projects

No projects listed.