Aik Choon Tan

Research interests

Publications

• Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion

  Proceedings of the National Academy of Sciences · 2021 · 10.1073/pnas.2000915118

• The mutational landscape of mucosal melanoma

  Seminars in Cancer Biology · 2019 · https://doi.org/10.1016/j.semcancer.2019.09.013

• Comprehensive Genetic Characterization of Human Thyroid Cancer Cell Lines: A Validated Panel for Preclinical Studies

  Clinical Cancer Research · 2019 · 10.1158/1078-0432.ccr-18-2953

• AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells

  Cell stem cell · 2018 · 10.1016/j.stem.2018.05.021

• Genetic Analysis of 779 Advanced Differentiated and Anaplastic Thyroid Cancers

  Clinical Cancer Research · 2018 · https://doi.org/10.1158/1078-0432.ccr-18-0373

• GSEA-InContext: identifying novel and common patterns in expression experiments

  Bioinformatics · 2018 · https://doi.org/10.1093/bioinformatics/bty271

• Resistance to Radiotherapy and PD-L1 Blockade Is Mediated by TIM-3 Upregulation and Regulatory T-Cell Infiltration

  Clinical Cancer Research · 2018 · 10.1158/1078-0432.ccr-18-1038

• Whole-exome sequencing identifies recurrent SF3B1 R625 mutation and comutation of NF1 and KIT in mucosal melanoma

  Melanoma Research · 2017 · 10.1097/cmr.0000000000000345

• Fibroblast Subtypes Regulate Responsiveness of Luminal Breast Cancer to Estrogen

  Clinical Cancer Research · 2016 · https://doi.org/10.1158/1078-0432.ccr-15-2851

• Systems biology approaches for advancing the discovery of effective drug combinations

  Journal of Cheminformatics · 2015 · 10.1186/s13321-015-0055-9

• DSigDB: drug signatures database for gene set analysis

  Bioinformatics · 2015 · https://doi.org/10.1093/bioinformatics/btv313

• A patient tumor transplant model of squamous cell cancer identifies PI3K inhibitors as candidate therapeutics in defined molecular bins

  Molecular Oncology · 2013 · 10.1016/j.molonc.2013.03.004

• A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop

  Oncogenesis · 2013 · https://doi.org/10.1038/oncsis.2013.4

• Patient-derived tumour xenografts as models for oncology drug development

  Nature Reviews Clinical Oncology · 2012 · https://doi.org/10.1038/nrclinonc.2012.61

• The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer

  Oncogene · 2012 · 10.1038/onc.2012.11

• Plasma-Based Circulating MicroRNA Biomarkers for Parkinson's Disease

  Journal of Parkinson s Disease · 2012 · 10.3233/jpd-012144

• Tumor Engraftment in Nude Mice and Enrichment in Stroma- Related Gene Pathways Predict Poor Survival and Resistance to Gemcitabine in Patients with Pancreatic Cancer

  Clinical Cancer Research · 2011 · https://doi.org/10.1158/1078-0432.ccr-11-0341

• A DNA methylation fingerprint of 1628 human samples

  Genome Research · 2011 · https://doi.org/10.1101/gr.119867.110

• Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2

  Nature Medicine · 2011 · 10.1038/nm.2416

• Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells

  Cell Research · 2011 · 10.1038/cr.2011.181

• Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy

  Nature Medicine · 2011 · https://doi.org/10.1038/nm.2385

• Optimizing the Detection of Lung Cancer Patients Harboring Anaplastic Lymphoma Kinase (ALK) Gene Rearrangements Potentially Suitable for ALK Inhibitor Treatment

  Clinical Cancer Research · 2010 · 10.1158/1078-0432.ccr-10-0851

• Colonoscopic perforations: a review of 30,366 patients

  Surgical Endoscopy · 2007 · 10.1007/s00464-007-9251-7

• Simple decision rules for classifying human cancers from gene expression profiles

  Computer applications in the biosciences · 2005 · 10.1093/bioinformatics/bti631

• Ensemble machine learning on gene expression data for cancer classification.

  PubMed · 2003

Current projects

No projects listed.