Wim Timens

Research interests

Publications

• An integrated cell atlas of the lung in health and disease

  Nature Medicine · 2023 · https://doi.org/10.1038/s41591-023-02327-2

• Immune microenvironment composition in non‐small cell lung cancer and its association with survival

  Clinical & Translational Immunology · 2020 · https://doi.org/10.1002/cti2.1142

• Angiotensin‐converting enzyme 2 ( ACE2 ), SARS‐CoV ‐2 and the pathophysiology of coronavirus disease 2019 ( COVID ‐19)

  The Journal of Pathology · 2020 · https://doi.org/10.1002/path.5471

• The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease

  American Journal of Respiratory Cell and Molecular Biology · 2019 · https://doi.org/10.1165/rcmb.2018-0416tr

• A cellular census of human lungs identifies novel cell states in health and in asthma

  Nature Medicine · 2019 · https://doi.org/10.1038/s41591-019-0468-5

• Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis

  American Journal of Respiratory and Critical Care Medicine · 2019 · https://doi.org/10.1164/rccm.201905-1017oc

• Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?

  European Respiratory Review · 2017 · https://doi.org/10.1183/16000617.0073-2017

• Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

  Nature Genetics · 2017 · https://doi.org/10.1038/ng.3752

• Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study

  The Lancet Respiratory Medicine · 2017 · https://doi.org/10.1016/s2213-2600(17)30387-9

• Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

  Nature Genetics · 2012 · https://doi.org/10.1038/ng.2396

• Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma

  PLoS Genetics · 2012 · https://doi.org/10.1371/journal.pgen.1003029

• Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

  Cancer Discovery · 2011 · https://doi.org/10.1158/2159-8274.cd-11-0005

• Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer

  Science Translational Medicine · 2010 · https://doi.org/10.1126/scitranslmed.3001451

• Management of Lung Nodules Detected by Volume CT Scanning

  New England Journal of Medicine · 2009 · https://doi.org/10.1056/nejmoa0906085

• The Pathology of Chronic Obstructive Pulmonary Disease

  Annual Review of Pathology Mechanisms of Disease · 2008 · https://doi.org/10.1146/annurev.pathol.4.110807.092145

• The emerging role of ACE2 in physiology and disease

  The Journal of Pathology · 2007 · https://doi.org/10.1002/path.2162

• Thymic epithelial tumours: A population-based study of the incidence, diagnostic procedures and therapy

  European Journal of Cancer · 2007 · https://doi.org/10.1016/j.ejca.2007.11.004

• Remodeling in Asthma and Chronic Obstructive Pulmonary Disease

  Proceedings of the American Thoracic Society · 2006 · https://doi.org/10.1513/pats.200601-006aw

• Cigarette Smoke–induced Emphysema

  American Journal of Respiratory and Critical Care Medicine · 2006 · https://doi.org/10.1164/rccm.200504-594oc

• Female mice are more susceptible to the development of allergic airway inflammation than male mice

  Clinical & Experimental Allergy · 2005 · https://doi.org/10.1111/j.1365-2222.2005.02362.x

• Effect of 1-year smoking cessation on airway inflammation in COPD and asymptomatic smokers

  European Respiratory Journal · 2005 · https://doi.org/10.1183/09031936.05.00108904

• The impact of smoking cessation on respiratory symptoms, lung function, airway hyperresponsiveness and inflammation

  European Respiratory Journal · 2004 · https://doi.org/10.1183/09031936.04.00012704

• Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis

  The Journal of Pathology · 2004 · https://doi.org/10.1002/path.1570

• Comparison of induced sputum with bronchial wash, bronchoalveolar lavage and bronchial biopsies in COPD

  European Respiratory Journal · 2000 · https://doi.org/10.1183/09031936.00.15110900

• Immaturity of the human splenic marginal zone in infancy. Possible contribution to the deficient infant immune response.

  The Journal of Immunology · 1989 · https://doi.org/10.4049/jimmunol.143.10.3200

Current projects

No projects listed.