Harry J.M. Groen

Research interests

Publications

• Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial

  New England Journal of Medicine · 2020 · https://doi.org/10.1056/nejmoa1911793

• Immune microenvironment composition in non‐small cell lung cancer and its association with survival

  Clinical & Translational Immunology · 2020 · https://doi.org/10.1002/cti2.1142

• Capmatinib in MET Exon 14–Mutated or MET -Amplified Non–Small-Cell Lung Cancer

  New England Journal of Medicine · 2020 · https://doi.org/10.1056/nejmoa2002787

• Dabrafenib plus trametinib in patients with previously untreated BRAFV600E-mutant metastatic non-small-cell lung cancer: an open-label, phase 2 trial

  The Lancet Oncology · 2017 · https://doi.org/10.1016/s1470-2045(17)30679-4

• Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

  Nature Genetics · 2017 · https://doi.org/10.1038/ng.3752

• Multicenter Phase II Study of Whole-Body and Intracranial Activity With Ceritinib in Patients With ALK -Rearranged Non–Small-Cell Lung Cancer Previously Treated With Chemotherapy and Crizotinib: Results From ASCEND-2

  Journal of Clinical Oncology · 2016 · https://doi.org/10.1200/jco.2015.65.5936

• Complication rates of CT-guided transthoracic lung biopsy: meta-analysis

  European Radiology · 2016 · https://doi.org/10.1007/s00330-016-4357-8

• Dabrafenib plus trametinib in patients with previously treated BRAFV600E-mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial

  The Lancet Oncology · 2016 · https://doi.org/10.1016/s1470-2045(16)30146-2

• Dabrafenib in patients with BRAFV600E-positive advanced non-small-cell lung cancer: a single-arm, multicentre, open-label, phase 2 trial

  The Lancet Oncology · 2016 · https://doi.org/10.1016/s1470-2045(16)00077-2

• Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer: a pooled analysis of two randomised trials

  The Lancet Oncology · 2015 · https://doi.org/10.1016/s1470-2045(15)70168-3

• Lung cancer probability in patients with CT-detected pulmonary nodules: a prespecified analysis of data from the NELSON trial of low-dose CT screening

  The Lancet Oncology · 2014 · https://doi.org/10.1016/s1470-2045(14)70389-4

• Characteristics of Lung Cancers Detected by Computer Tomography Screening in the Randomized NELSON Trial

  American Journal of Respiratory and Critical Care Medicine · 2013 · https://doi.org/10.1164/rccm.201209-1651oc

• Randomized Phase III Trial of Maintenance Bevacizumab With or Without Pemetrexed After First-Line Induction With Bevacizumab, Cisplatin, and Pemetrexed in Advanced Nonsquamous Non–Small-Cell Lung Cancer: AVAPERL (MO22089)

  Journal of Clinical Oncology · 2013 · https://doi.org/10.1200/jco.2012.42.3749

• Unraveling the Regulatory Mechanisms Underlying Tissue-Dependent Genetic Variation of Gene Expression

  PLoS Genetics · 2012 · https://doi.org/10.1371/journal.pgen.1002431

• Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

  Nature Genetics · 2012 · https://doi.org/10.1038/ng.2396

• Circulating tumor cells in small-cell lung cancer: a predictive and prognostic factor

  Annals of Oncology · 2012 · https://doi.org/10.1093/annonc/mds138

• Trans-eQTLs Reveal That Independent Genetic Variants Associated with a Complex Phenotype Converge on Intermediate Genes, with a Major Role for the HLA

  PLoS Genetics · 2011 · https://doi.org/10.1371/journal.pgen.1002197

• Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

  Cancer Discovery · 2011 · https://doi.org/10.1158/2159-8274.cd-11-0005

• Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer

  Science Translational Medicine · 2010 · https://doi.org/10.1126/scitranslmed.3001451

• Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

  Nature Genetics · 2010 · https://doi.org/10.1038/ng.716

• Multiple common variants for celiac disease influencing immune gene expression

  Nature Genetics · 2010 · 10.1038/ng.543

• Management of Lung Nodules Detected by Volume CT Scanning

  New England Journal of Medicine · 2009 · https://doi.org/10.1056/nejmoa0906085

• Thymic epithelial tumours: A population-based study of the incidence, diagnostic procedures and therapy

  European Journal of Cancer · 2007 · https://doi.org/10.1016/j.ejca.2007.11.004

• Expression of TRAIL and TRAIL death receptors in stage III non-small cell lung cancer tumors.

  PubMed · 2003

Current projects

No projects listed.