Herman S. Overkleeft

Research interests

Publications

• Acceptor reactivity in glycosylation reactions

  Chemical Society Reviews · 2019 · https://doi.org/10.1039/c8cs00369f

• Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

  Science · 2017 · https://doi.org/10.1126/science.aaf7497

• Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses

  Nucleic Acids Research · 2015 · https://doi.org/10.1093/nar/gkv838

• Subclassification and Biochemical Analysis of Plant Papain-Like Cysteine Proteases Displays Subfamily-Specific Characteristics

  PLANT PHYSIOLOGY · 2012 · https://doi.org/10.1104/pp.112.194001

• Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

  Chemistry & Biology · 2012 · https://doi.org/10.1016/j.chembiol.2012.01.003

• Asymmetric Proteasome Segregation as a Mechanism for Unequal Partitioning of the Transcription Factor T-bet during T Lymphocyte Division

  Immunity · 2011 · https://doi.org/10.1016/j.immuni.2011.03.017

• Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response

  Blood · 2011 · https://doi.org/10.1182/blood-2011-05-352971

• Ultrasensitive in situ visualization of active glucocerebrosidase molecules

  Nature Chemical Biology · 2010 · https://doi.org/10.1038/nchembio.466

• Muscle Wasting in Aged, Sarcopenic Rats Is Associated with Enhanced Activity of the Ubiquitin Proteasome Pathway

  Journal of Biological Chemistry · 2010 · https://doi.org/10.1074/jbc.m110.129718

• Glycosphingolipids—Nature, Function, and Pharmacological Modulation

  Angewandte Chemie International Edition · 2009 · https://doi.org/10.1002/anie.200902620

• Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1

  Nature · 2007 · https://doi.org/10.1038/nature06345

• Pharmacological Inhibition of Glucosylceramide Synthase Enhances Insulin Sensitivity

  Diabetes · 2007 · https://doi.org/10.2337/db06-1619

• A Fluorescent Broad-Spectrum Proteasome Inhibitor for Labeling Proteasomes In Vitro and In Vivo

  Chemistry & Biology · 2006 · https://doi.org/10.1016/j.chembiol.2006.09.013

• Thioglycosides in sequential glycosylation strategies

  Chemical Society Reviews · 2005 · https://doi.org/10.1039/b417138c

• The Caspase-like Sites of Proteasomes, Their Substrate Specificity, New Inhibitors and Substrates, and Allosteric Interactions with the Trypsin-like Sites

  Journal of Biological Chemistry · 2003 · https://doi.org/10.1074/jbc.m303725200

• Ph2SO/Tf2O: a Powerful Promotor System in Chemoselective Glycosylations Using Thioglycosides

  Organic Letters · 2003 · https://doi.org/10.1021/ol034312t

• Analysis of Protease Activity in Live Antigen-presenting Cells Shows Regulation of the Phagosomal Proteolytic Contents During Dendritic Cell Activation

  The Journal of Experimental Medicine · 2002 · https://doi.org/10.1084/jem.20020327

• A novel active site‐directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14

  The EMBO Journal · 2001 · https://doi.org/10.1093/emboj/20.18.5187

Current projects

No projects listed.