Gerard H. Koppelman

Research interests

Publications

• Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

  Cell Reports · 2019 · 10.1016/j.celrep.2019.01.068

• Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct

  The American Journal of Human Genetics · 2019 · 10.1016/j.ajhg.2019.02.022

• A cellular census of human lungs identifies novel cell states in health and in asthma

  Nature Medicine · 2019 · https://doi.org/10.1038/s41591-019-0468-5

• The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease

  American Journal of Respiratory Cell and Molecular Biology · 2019 · 10.1165/rcmb.2018-0416tr

• DNA methylation in childhood asthma: an epigenome-wide meta-analysis

  The Lancet Respiratory Medicine · 2018 · 10.1016/s2213-2600(18)30052-3

• Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

  Nature Genetics · 2017 · https://doi.org/10.1038/s41588-017-0014-7

• Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

  Nature Genetics · 2017 · https://doi.org/10.1038/ng.3985

• Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium

  Human Molecular Genetics · 2017 · 10.1093/hmg/ddx290

• Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure

  Environmental Health Perspectives · 2016 · 10.1289/ehp36

• Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma

  New England Journal of Medicine · 2016 · https://doi.org/10.1056/nejmoa1513737

• Exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence: a population-based birth cohort study

  The Lancet Respiratory Medicine · 2015 · 10.1016/s2213-2600(15)00426-9

• Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

  Human Molecular Genetics · 2015 · 10.1093/hmg/ddv472

• Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-IgE-sensitised children in MeDALL: a population-based cohort study

  The Lancet Respiratory Medicine · 2014 · 10.1016/s2213-2600(13)70277-7

• Air Pollution and Respiratory Infections during Early Childhood: An Analysis of 10 European Birth Cohorts within the ESCAPE Project

  Environmental Health Perspectives · 2013 · https://doi.org/10.1289/ehp.1306755

• Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

  Nature Genetics · 2013 · 10.1038/ng.2694

• Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma

  PLoS Genetics · 2012 · https://doi.org/10.1371/journal.pgen.1003029

• Comparison of childhood wheezing phenotypes in 2 birth cohorts: ALSPAC and PIAMA

  Journal of Allergy and Clinical Immunology · 2011 · 10.1016/j.jaci.2011.02.002

• Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

  Nature Genetics · 2011 · 10.1038/ng.1017

• Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy

  Journal of Allergy and Clinical Immunology · 2011 · 10.1016/j.jaci.2011.07.027

• Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

  Nature Genetics · 2010 · 10.1038/ng.567

• Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

  Nature Genetics · 2009 · https://doi.org/10.1038/ng.323

• Fine Mapping and Positional Candidate Studies Identify HLA-G as an Asthma Susceptibility Gene on Chromosome 6p21

  The American Journal of Human Genetics · 2005 · 10.1086/427763

• Gene-Gene Interaction in Asthma: IL4RA and IL13 in a Dutch Population with Asthma

  The American Journal of Human Genetics · 2002 · 10.1086/338242

• Association of a Promoter Polymorphism of the CD14 Gene and Atopy

  American Journal of Respiratory and Critical Care Medicine · 2001 · 10.1164/ajrccm.163.4.2004164

• Identification and Association of Polymorphisms in the Interleukin-13 Gene with Asthma and Atopy in a Dutch Population

  American Journal of Respiratory Cell and Molecular Biology · 2001 · 10.1165/ajrcmb.25.3.4483

Current projects

No projects listed.