Casper G. Schalkwijk

Research interests

Publications

• Methylglyoxal, a Highly Reactive Dicarbonyl Compound, in Diabetes, Its Vascular Complications, and Other Age-Related Diseases

  Physiological Reviews · 2019 · https://doi.org/10.1152/physrev.00001.2019

• Abdominal subcutaneous and visceral adipocyte size, lipolysis and inflammation relate to insulin resistance in male obese humans

  Scientific Reports · 2018 · 10.1038/s41598-018-22962-x

• Abdominal subcutaneous and visceral adipocyte size, lipolysis and inflammation relate to insulin resistance in male obese humans

  Scientific Reports · 2018 · 10.1038/s41598-018-22962-x

• Inflammation and premature aging in advanced chronic kidney disease

  American Journal of Physiology-Renal Physiology · 2017 · 10.1152/ajprenal.00256.2017

• Inflammation and premature aging in advanced chronic kidney disease

  American Journal of Physiology-Renal Physiology · 2017 · 10.1152/ajprenal.00256.2017

• DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation

  The American Journal of Human Genetics · 2017 · https://doi.org/10.1016/j.ajhg.2017.09.028

• Disease variants alter transcription factor levels and methylation of their binding sites

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3721

• Identification of context-dependent expression quantitative trait loci in whole blood

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3737

• Genetic and environmental influences interact with age and sex in shaping the human methylome

  Nature Communications · 2016 · https://doi.org/10.1038/ncomms11115

• The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases

  Clinical Science · 2015 · https://doi.org/10.1042/cs20140683

• Analysis of advanced glycation endproducts in selected food items by ultra-performance liquid chromatography tandem mass spectrometry: Presentation of a dietary AGE database

  Food Chemistry · 2015 · https://doi.org/10.1016/j.foodchem.2015.06.049

• Obesity-associated low-grade inflammation in type 2 diabetes mellitus: causes and consequences.

  PubMed · 2013

• Obesity-associated low-grade inflammation in type 2 diabetes mellitus: causes and consequences.

  PubMed · 2013

• Dietary factors and low-grade inflammation in relation to overweight and obesity

  British Journal Of Nutrition · 2011 · https://doi.org/10.1017/s0007114511005460

• Higher Plasma Levels of Advanced Glycation End Products Are Associated With Incident Cardiovascular Disease and All-Cause Mortality in Type 1 Diabetes

  Diabetes Care · 2011 · 10.2337/dc10-1087

• Higher Plasma Levels of Advanced Glycation End Products Are Associated With Incident Cardiovascular Disease and All-Cause Mortality in Type 1 Diabetes

  Diabetes Care · 2011 · 10.2337/dc10-1087

• Diabetes Mellitus Worsens Diastolic Left Ventricular Dysfunction in Aortic Stenosis Through Altered Myocardial Structure and Cardiomyocyte Stiffness

  Circulation · 2011 · 10.1161/circulationaha.111.025270

• Diabetes Mellitus Worsens Diastolic Left Ventricular Dysfunction in Aortic Stenosis Through Altered Myocardial Structure and Cardiomyocyte Stiffness

  Circulation · 2011 · 10.1161/circulationaha.111.025270

• Overexpression of Glyoxalase-I Reduces Hyperglycemia-induced Levels of Advanced Glycation End Products and Oxidative Stress in Diabetic Rats

  Journal of Biological Chemistry · 2010 · 10.1074/jbc.m110.144097

• Overexpression of Glyoxalase-I Reduces Hyperglycemia-induced Levels of Advanced Glycation End Products and Oxidative Stress in Diabetic Rats

  Journal of Biological Chemistry · 2010 · 10.1074/jbc.m110.144097

• Diastolic Stiffness of the Failing Diabetic Heart

  Circulation · 2007 · https://doi.org/10.1161/circulationaha.107.728550

• Vascular complications in diabetes mellitus: the role of endothelial dysfunction

  Clinical Science · 2005 · https://doi.org/10.1042/cs20050025

• Markers of inflammation are cross-sectionally associated with microvascular complications and cardiovascular disease in type 1 diabetes?the EURODIAB Prospective Complications Study

  Diabetologia · 2005 · https://doi.org/10.1007/s00125-004-1628-8

• Fructose‐mediated non‐enzymatic glycation: sweet coupling or bad modification

  Diabetes/Metabolism Research and Reviews · 2004 · 10.1002/dmrr.488

• Effects of short‐term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized, placebo‐controlled trial

  Journal of Internal Medicine · 2004 · 10.1111/j.1365-2796.2004.01420.x

• Fructose‐mediated non‐enzymatic glycation: sweet coupling or bad modification

  Diabetes/Metabolism Research and Reviews · 2004 · 10.1002/dmrr.488

• Effects of short‐term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized, placebo‐controlled trial

  Journal of Internal Medicine · 2004 · 10.1111/j.1365-2796.2004.01420.x

• Vascular Risk Factors and Markers of Endothelial Function as Determinants of Inflammatory Markers in Type 1 Diabetes

  Diabetes Care · 2003 · 10.2337/diacare.26.7.2165

• Vascular Risk Factors and Markers of Endothelial Function as Determinants of Inflammatory Markers in Type 1 Diabetes

  Diabetes Care · 2003 · 10.2337/diacare.26.7.2165

• Inflammatory Markers, Adiponectin, and Risk of Type 2 Diabetes in the Pima Indian

  Diabetes Care · 2003 · https://doi.org/10.2337/diacare.26.6.1745

• Humoral markers of inflammation and endothelial dysfunction in relation to adiposity and in vivo insulin action in Pima Indians

  Atherosclerosis · 2002 · 10.1016/s0021-9150(01)00626-8

• Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: A possible mechanism through which age is a risk factor for osteoarthritis

  Arthritis & Rheumatism · 2002 · https://doi.org/10.1002/1529-0131(200201)46:1<114::aid-art10025>3.0.co;2-p

• Humoral markers of inflammation and endothelial dysfunction in relation to adiposity and in vivo insulin action in Pima Indians

  Atherosclerosis · 2002 · 10.1016/s0021-9150(01)00626-8

• Associations of C-Reactive Protein With Measures of Obesity, Insulin Resistance, and Subclinical Atherosclerosis in Healthy, Middle-Aged Women

  Arteriosclerosis Thrombosis and Vascular Biology · 1999 · https://doi.org/10.1161/01.atv.19.8.1986

• Plasma concentration of C-reactive protein is increased in Type I diabetic patients without clinical macroangiopathy and correlates with markers of endothelial dysfunction: evidence for chronic inflammation

  Diabetologia · 1999 · https://doi.org/10.1007/s001250051162

Current projects

No projects listed.