Peter Pickkers

Research interests

Publications

• The pathophysiology of sepsis and precision-medicine-based immunotherapy

  Nature Immunology · 2024 · 10.1038/s41590-023-01660-5

• Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup

  Nature Reviews Nephrology · 2023 · https://doi.org/10.1038/s41581-023-00683-3

• A guide to immunotherapy for COVID-19

  Nature Medicine · 2022 · 10.1038/s41591-021-01643-9

• Acute kidney injury in the critically ill: an updated review on pathophysiology and management

  Intensive Care Medicine · 2021 · 10.1007/s00134-021-06454-7

• Swarm Learning for decentralized and confidential clinical machine learning

  Nature · 2021 · https://doi.org/10.1038/s41586-021-03583-3

• Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

  Genome Medicine · 2021 · 10.1186/s13073-020-00823-5

• Sepsis-Induced Immunosuppression

  Annual Review of Physiology · 2021 · 10.1146/annurev-physiol-061121-040214

• Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

  Immunity · 2020 · https://doi.org/10.1016/j.immuni.2020.11.017

• Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions

  JAMA · 2020 · 10.1001/jama.2020.17052

• COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup

  Nature Reviews Nephrology · 2020 · 10.1038/s41581-020-00356-5

• Recommendations on Acute Kidney Injury Biomarkers From the Acute Disease Quality Initiative Consensus Conference

  JAMA Network Open · 2020 · https://doi.org/10.1001/jamanetworkopen.2020.19209

• Obesity in the critically ill: a narrative review

  Intensive Care Medicine · 2019 · https://doi.org/10.1007/s00134-019-05594-1

• Cardiac and Vascular Surgery–Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group

  Journal of the American Heart Association · 2018 · 10.1161/jaha.118.008834

• The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity

  Cell Metabolism · 2018 · 10.1016/j.cmet.2018.09.003

• A guiding map for inflammation

  Nature Immunology · 2017 · https://doi.org/10.1038/ni.3790

• β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance

  Cell · 2016 · 10.1016/j.cell.2016.09.034

• Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

  Nature Immunology · 2016 · 10.1038/ni.3398

• Inflammation in AKI

  Journal of the American Society of Nephrology · 2015 · 10.1681/asn.2015030261

• Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans

  Proceedings of the National Academy of Sciences · 2014 · 10.1073/pnas.1322174111

• A Unified Theory of Sepsis-Induced Acute Kidney Injury

  Shock · 2013 · https://doi.org/10.1097/shk.0000000000000052

• Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for intensive care patients: observational multicentre study

  BMJ · 2012 · 10.1136/bmj.e420

• A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1

  Journal of Clinical Investigation · 2011 · https://doi.org/10.1172/jci57990

• Delirium in critically ill patients

  Critical Care Medicine · 2011 · 10.1097/ccm.0b013e31822e9fc9

• Decontamination of the Digestive Tract and Oropharynx in ICU Patients

  New England Journal of Medicine · 2008 · https://doi.org/10.1056/nejmoa0800394

• Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS

  Blood · 2005 · 10.1182/blood-2005-03-1159

Current projects

No projects listed.