Henk‐Jan Guchelaar

Research interests

Publications

• A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study

  The Lancet · 2023 · https://doi.org/10.1016/s0140-6736(22)01841-4

• Phenoconversion of Cytochrome P450 Metabolism: A Systematic Review

  Journal of Clinical Medicine · 2020 · https://doi.org/10.3390/jcm9092890

• Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene–drug interaction of DPYD and fluoropyrimidines

  European Journal of Human Genetics · 2019 · https://doi.org/10.1038/s41431-019-0540-0

• A Review of Mathematical Models for Tumor Dynamics and Treatment Resistance Evolution of Solid Tumors

  CPT Pharmacometrics & Systems Pharmacology · 2019 · https://doi.org/10.1002/psp4.12450

• Standardizing CYP 2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group

  Clinical and Translational Science · 2019 · https://doi.org/10.1111/cts.12692

• Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy

  Clinical Pharmacology & Therapeutics · 2018 · https://doi.org/10.1002/cpt.1007

• DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis

  The Lancet Oncology · 2018 · https://doi.org/10.1016/s1470-2045(18)30686-7

• Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium

  Clinical Pharmacology & Therapeutics · 2016 · 10.1002/cpt.602

• Making sense of big data in health research: Towards an EU action plan

  Genome Medicine · 2016 · https://doi.org/10.1186/s13073-016-0323-y

• Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium

  Clinical Pharmacology & Therapeutics · 2016 · 10.1002/cpt.602

• Identification of Patients With Variants in TPMT and Dose Reduction Reduces Hematologic Events During Thiopurine Treatment of Inflammatory Bowel Disease

  Gastroenterology · 2015 · https://doi.org/10.1053/j.gastro.2015.06.002

• Genetics of rheumatoid arthritis contributes to biology and drug discovery

  Nature · 2013 · https://doi.org/10.1038/nature12873

• Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis

  PLoS Genetics · 2013 · https://doi.org/10.1371/journal.pgen.1003394

• Pharmacogenetics: From Bench to Byte— An Update of Guidelines

  Clinical Pharmacology & Therapeutics · 2011 · 10.1038/clpt.2011.34

• Liposomal drug formulations in cancer therapy: 15 years along the road

  Drug Discovery Today · 2011 · https://doi.org/10.1016/j.drudis.2011.09.015

• Pharmacogenetics: From Bench to Byte— An Update of Guidelines

  Clinical Pharmacology & Therapeutics · 2011 · 10.1038/clpt.2011.34

• Relationship between Single Nucleotide Polymorphisms and Haplotypes in DPYD and Toxicity and Efficacy of Capecitabine in Advanced Colorectal Cancer

  Clinical Cancer Research · 2011 · https://doi.org/10.1158/1078-0432.ccr-10-2209

• Pharmacogenetic Pathway Analysis for Determination of Sunitinib-Induced Toxicity

  Journal of Clinical Oncology · 2009 · https://doi.org/10.1200/jco.2008.21.7679

• Clinical pharmacokinetics of tyrosine kinase inhibitors

  Cancer Treatment Reviews · 2009 · https://doi.org/10.1016/j.ctrv.2009.08.004

• Pharmacogenetics: From Bench to Byte

  Clinical Pharmacology & Therapeutics · 2008 · 10.1038/sj.clpt.6100507

• Pharmacogenetics: From Bench to Byte

  Clinical Pharmacology & Therapeutics · 2008 · 10.1038/sj.clpt.6100507

• A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent‐onset rheumatoid arthritis

  Arthritis & Rheumatism · 2007 · https://doi.org/10.1002/art.22640

• Translating Pharmacogenomics: Challenges on the Road to the Clinic

  PLoS Medicine · 2007 · https://doi.org/10.1371/journal.pmed.0040209

• Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis

  Lara D. Veeken · 2007 · https://doi.org/10.1093/rheumatology/kem279

• Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single‐nucleotide polymorphisms in genes coding for folate pathway enzymes

  Arthritis & Rheumatism · 2006 · https://doi.org/10.1002/art.21726

• Effects of statins and farnesyltransferase inhibitors on the development and progression of cancer

  Cancer Treatment Reviews · 2004 · https://doi.org/10.1016/j.ctrv.2004.06.010

• The Risk of Cancer in Users of Statins

  Journal of Clinical Oncology · 2004 · https://doi.org/10.1200/jco.2004.02.027

• Cardiotoxicity of cytotoxic drugs

  Cancer Treatment Reviews · 2003 · https://doi.org/10.1016/j.ctrv.2003.07.003

• Radiation-induced xerostomia: pathophysiology, clinical course and supportive treatment

  Supportive Care in Cancer · 1997 · https://doi.org/10.1007/s005200050075

Current projects

No projects listed.