Huib A.M. Kerstjens

Research interests

Publications

• Efficacy and safety of once-daily single-inhaler triple therapy (FF/UMEC/VI) versus FF/VI in patients with inadequately controlled asthma (CAPTAIN): a double-blind, randomised, phase 3A trial

  The Lancet Respiratory Medicine · 2020 · 10.1016/s2213-2600(20)30389-1

• Artificial intelligence outperforms pulmonologists in the interpretation of pulmonary function tests

  European Respiratory Journal · 2019 · https://doi.org/10.1183/13993003.01660-2018

• Home initiation of chronic non-invasive ventilation in COPD patients with chronic hypercapnic respiratory failure: a randomised controlled trial

  Thorax · 2019 · https://doi.org/10.1136/thoraxjnl-2019-213303

• Mepolizumab for Eosinophilic Chronic Obstructive Pulmonary Disease

  New England Journal of Medicine · 2017 · https://doi.org/10.1056/nejmoa1708208

• Endobronchial Valves for Emphysema without Interlobar Collateral Ventilation

  New England Journal of Medicine · 2015 · 10.1056/nejmoa1507807

• Nocturnal non-invasive ventilation in COPD patients with prolonged hypercapnia after ventilatory support for acute respiratory failure: a randomised, controlled, parallel-group study

  Thorax · 2014 · 10.1136/thoraxjnl-2014-205126

• Obesity in asthma: more neutrophilic inflammation as a possible explanation for a reduced treatment response

  Allergy · 2012 · https://doi.org/10.1111/j.1398-9995.2012.02855.x

• Tiotropium in Asthma Poorly Controlled with Standard Combination Therapy

  New England Journal of Medicine · 2012 · https://doi.org/10.1056/nejmoa1208606

• Activation of WNT / β-Catenin Signaling in Pulmonary Fibroblasts by TGF-β1 Is Increased in Chronic Obstructive Pulmonary Disease

  PLoS ONE · 2011 · https://doi.org/10.1371/journal.pone.0025450

• Bronchoscopic Lung Volume Reduction Coil Treatment of Patients With Severe Heterogeneous Emphysema

  CHEST Journal · 2011 · 10.1378/chest.11-0730

• Tiotropium improves lung function in patients with severe uncontrolled asthma: A randomized controlled trial

  Journal of Allergy and Clinical Immunology · 2011 · 10.1016/j.jaci.2011.04.039

• Effect of Fluticasone With and Without Salmeterol on Pulmonary Outcomes in Chronic Obstructive Pulmonary Disease

  Annals of Internal Medicine · 2009 · 10.7326/0003-4819-151-8-200910200-00004

• Protein Tyrosine Nitration: Selectivity, Physicochemical and Biological Consequences, Denitration, and Proteomics Methods for the Identification of Tyrosine-Nitrated Proteins

  Journal of Proteome Research · 2009 · 10.1021/pr900039c

• An Official American Thoracic Society/European Respiratory Society Statement: Asthma Control and Exacerbations

  American Journal of Respiratory and Critical Care Medicine · 2009 · https://doi.org/10.1164/rccm.200801-060st

• A new perspective on concepts of asthma severity and control

  European Respiratory Journal · 2008 · https://doi.org/10.1183/09031936.00155307

• Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD: a pilot study

  European Respiratory Journal · 2007 · 10.1183/09031936.00163206

• Cigarette Smoke–induced Emphysema

  American Journal of Respiratory and Critical Care Medicine · 2006 · https://doi.org/10.1164/rccm.200504-594oc

• Female mice are more susceptible to the development of allergic airway inflammation than male mice

  Clinical & Experimental Allergy · 2005 · 10.1111/j.1365-2222.2005.02362.x

• Efficacy and safety of a recombinant anti‐immunoglobulin E antibody (omalizumab) in severe allergic asthma

  Clinical & Experimental Allergy · 2004 · https://doi.org/10.1111/j.1365-2222.2004.1916.x

• Effect of SCH55700, a Humanized Anti-Human Interleukin-5 Antibody, in Severe Persistent Asthma: A Pilot Study

  American Journal of Respiratory and Critical Care Medicine · 2003 · https://doi.org/10.1164/rccm.200206-525oc

• PC20 Adenosine 5′-Monophosphate Is More Closely Associated with Airway Inflammation in Asthma Than PC20 Methacholine

  American Journal of Respiratory and Critical Care Medicine · 2001 · https://doi.org/10.1164/ajrccm.163.7.2010145

• Corticosteroid-induced Improvement in the PC20 of Adenosine Monophosphate Is More Closely Associated with Reduction in Airway Inflammation than Improvement in the PC20 of Methacholine

  American Journal of Respiratory and Critical Care Medicine · 2001 · 10.1164/ajrccm.164.7.2102135

• Characteristics of Airway Hyperresponsiveness in Asthma and Chronic Obstructive Pulmonary Disease

  American Journal of Respiratory and Critical Care Medicine · 1998 · https://doi.org/10.1164/ajrccm.158.supplement_2.13tac170

• Decline of FEV1 by age and smoking status: facts, figures, and fallacies

  Thorax · 1997 · 10.1136/thx.52.9.820

• Interpretation of bronchodilator response in patients with obstructive airways disease. The Dutch Chronic Non-Specific Lung Disease (CNSLD) Study Group.

  Thorax · 1992 · https://doi.org/10.1136/thx.47.6.429

• A Comparison of Bronchodilator Therapy with or without Inhaled Corticosteroid Therapy for Obstructive Airways Disease

  New England Journal of Medicine · 1992 · 10.1056/nejm199211123272003

Current projects

No projects listed.