Pieter S. Hiemstra

Research interests

Publications

• Role of air pollutants in airway epithelial barrier dysfunction in asthma and COPD

  European Respiratory Review · 2022 · 10.1183/16000617.0112-2021

• An emerging class of air pollutants: Potential effects of microplastics to respiratory human health?

  The Science of The Total Environment · 2020 · 10.1016/j.scitotenv.2020.141676

• Air–Liquid Interface In Vitro Models for Respiratory Toxicology Research: Consensus Workshop and Recommendations

  Applied In Vitro Toxicology · 2018 · 10.1089/aivt.2017.0034

• Airway Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease: Role of Cigarette Smoke Exposure

  American Journal of Respiratory Cell and Molecular Biology · 2017 · 10.1165/rcmb.2017-0200tr

• Human lung epithelial cell cultures for analysis of inhaled toxicants: Lessons learned and future directions

  Toxicology in Vitro · 2017 · 10.1016/j.tiv.2017.11.005

• Asthma–COPD Overlap. Clinical Relevance of Genomic Signatures of Type 2 Inflammation in Chronic Obstructive Pulmonary Disease

  American Journal of Respiratory and Critical Care Medicine · 2015 · 10.1164/rccm.201408-1458oc

• Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development

  Nature Communications · 2015 · https://doi.org/10.1038/ncomms7356

• The innate immune function of airway epithelial cells in inflammatory lung disease

  European Respiratory Journal · 2015 · 10.1183/09031936.00141514

• Efficient and sensitive identification and quantification of airborne pollen using next‐generation DNA sequencing

  Molecular Ecology Resources · 2014 · 10.1111/1755-0998.12288

• Extracellular matrix composition in COPD

  European Respiratory Journal · 2012 · https://doi.org/10.1183/09031936.00192611

• Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD

  Thorax · 2007 · 10.1136/thx.2006.075937

• Interleukin-8 stimulates cell proliferation in non-small cell lung cancer through epidermal growth factor receptor transactivation

  Lung Cancer · 2006 · 10.1016/j.lungcan.2006.11.014

• Human Cathelicidin LL-37 Is a Chemoattractant for Eosinophils and Neutrophils That Acts via Formyl-Peptide Receptors

  International Archives of Allergy and Immunology · 2006 · 10.1159/000092305

• High Expression Levels of Keratinocyte Antimicrobial Proteins in Psoriasis Compared with Atopic Dermatitis

  Journal of Investigative Dermatology · 2005 · 10.1111/j.0022-202x.2005.23935.x

• Innate immunity in the lung: how epithelial cells fight against respiratory pathogens

  European Respiratory Journal · 2004 · https://doi.org/10.1183/09031936.03.00098803

• An angiogenic role for the human peptide antibiotic LL-37/hCAP-18

  Journal of Clinical Investigation · 2003 · https://doi.org/10.1172/jci17545

• The Antimicrobial Peptide LL-37 Activates Innate Immunity at the Airway Epithelial Surface by Transactivation of the Epidermal Growth Factor Receptor

  The Journal of Immunology · 2003 · 10.4049/jimmunol.171.12.6690

• 4-Hydroxy-2-Nonenal, a Specific Lipid Peroxidation Product, Is Elevated in Lungs of Patients with Chronic Obstructive Pulmonary Disease

  American Journal of Respiratory and Critical Care Medicine · 2002 · https://doi.org/10.1164/rccm.2110101

• Expression of β‐defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells

  Immunology · 2002 · 10.1046/j.1365-2567.2002.01430.x

• In Vivo Expression of Toll-Like Receptor 2 and 4 by Renal Epithelial Cells: IFN-γ and TNF-α Mediated Up-Regulation During Inflammation

  The Journal of Immunology · 2002 · 10.4049/jimmunol.168.3.1286

• Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3

  Blood · 2001 · https://doi.org/10.1182/blood.v97.12.3951

• Monocyte chemoattractant protein 1, interleukin 8, and chronic airways inflammation in COPD

  The Journal of Pathology · 2000 · 10.1002/(sici)1096-9896(200004)190:5<619::aid-path555>3.0.co;2-6

• Transforming Growth Factor β1 and Recruitment of Macrophages and Mast Cells in Airways in Chronic Obstructive Pulmonary Disease

  American Journal of Respiratory and Critical Care Medicine · 1998 · 10.1164/ajrccm.158.6.9803053

• Proteases fromAspergillus fumigatusInduce Release of Proinflammatory Cytokines and Cell Detachment in Airway Epithelial Cell Lines

  The Journal of Infectious Diseases · 1997 · 10.1086/517272

• Antibacterial activity of antileukoprotease

  Infection and Immunity · 1996 · 10.1128/iai.64.11.4520-4524.1996

• IFN-gamma-induced L-arginine-dependent toxoplasmastatic activity in murine peritoneal macrophages is mediated by endogenous tumor necrosis factor-alpha

  The Journal of Immunology · 1992 · 10.4049/jimmunol.148.2.568

Current projects

No projects listed.