Jan Köster

Research interests

Publications

• The landscape of genomic alterations across childhood cancers

  Nature · 2018 · https://doi.org/10.1038/nature25480

• The whole-genome landscape of medulloblastoma subtypes

  Nature · 2017 · https://doi.org/10.1038/nature22973

• Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

  Cancer Cell · 2016 · https://doi.org/10.1016/j.ccell.2016.02.001

• New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

  Cell · 2016 · 10.1016/j.cell.2016.01.015

• Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

  Cancer Cell · 2015 · https://doi.org/10.1016/j.ccell.2015.04.002

• Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations

  Nature Genetics · 2015 · https://doi.org/10.1038/ng.3333

• RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics

  Cancer Cell · 2015 · https://doi.org/10.1016/j.ccell.2015.09.018

• Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

  Cell · 2015 · https://doi.org/10.1016/j.cell.2015.03.053

• Mutations in the SIX1/2 Pathway and the DROSHA/DGCR8 miRNA Microprocessor Complex Underlie High-Risk Blastemal Type Wilms Tumors

  Cancer Cell · 2015 · https://doi.org/10.1016/j.ccell.2015.01.002

• Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

  Nature · 2014 · https://doi.org/10.1038/nature13108

• Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

  Nature · 2014 · https://doi.org/10.1038/nature13268

• Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

  Cancer Cell · 2014 · https://doi.org/10.1016/j.ccr.2014.02.004

• Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

  Nature · 2014 · https://doi.org/10.1038/nature13379

• Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

  Nature Genetics · 2013 · 10.1038/ng.2682

• Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

  Cell · 2012 · https://doi.org/10.1016/j.cell.2011.12.013

• Dissecting the genomic complexity underlying medulloblastoma

  Nature · 2012 · 10.1038/nature11284

• Clonal selection drives genetic divergence of metastatic medulloblastoma

  Nature · 2012 · https://doi.org/10.1038/nature10825

• Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

  Acta Neuropathologica · 2012 · https://doi.org/10.1007/s00401-012-0958-8

• The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

  The EMBO Journal · 2012 · https://doi.org/10.1038/emboj.2012.166

• Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

  Cancer Cell · 2012 · https://doi.org/10.1016/j.ccr.2012.08.024

Current projects

No projects listed.