Wilbert Zwart

Research interests

Publications

• MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling

  Nature Communications · 2022 · 10.1038/s41467-022-34000-6

• The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer

  Nature Medicine · 2021 · 10.1038/s41591-020-01168-7

• An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer

  Nature Cell Biology · 2021 · 10.1038/s41556-021-00743-5

• The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair

  Nature Communications · 2021 · 10.1038/s41467-020-20513-5

• The DNA methylation landscape of advanced prostate cancer

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-020-0648-8

• Genomic and phenotypic heterogeneity in prostate cancer

  Nature Reviews Urology · 2020 · https://doi.org/10.1038/s41585-020-00400-w

• Prostate cancer reactivates developmental epigenomic programs during metastatic progression

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-020-0664-8

• IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis

  Cancer Cell · 2020 · 10.1016/j.ccell.2020.06.007

• The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact

  Nature Communications · 2019 · 10.1038/s41467-019-13084-7

• Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis

  Nature · 2019 · 10.1038/s41586-019-1450-6

• Integrative epigenetic taxonomy of primary prostate cancer

  Nature Communications · 2018 · 10.1038/s41467-018-07270-2

• Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism

  Cell Reports · 2018 · 10.1016/j.celrep.2018.07.065

• Endogenous androgen receptor proteomic profiling reveals genomic subcomplex involved in prostate tumorigenesis

  Oncogene · 2017 · 10.1038/onc.2017.330

• Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance

  Nature Communications · 2017 · 10.1038/s41467-017-01864-y

• Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9

  Nature Biotechnology · 2016 · 10.1038/nbt.3450

• Interaction of 14-3-3 proteins with the Estrogen Receptor Alpha F domain provides a drug target interface

  Proceedings of the National Academy of Sciences · 2013 · 10.1073/pnas.1220809110

• Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

  Nature Communications · 2013 · 10.1038/ncomms2921

• Endogenous Purification Reveals GREB1 as a Key Estrogen Receptor Regulatory Factor

  Cell Reports · 2013 · 10.1016/j.celrep.2013.01.010

• Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis

  Proceedings of the National Academy of Sciences · 2013 · 10.1073/pnas.1222085110

• TRPM7 Is Required for Breast Tumor Cell Metastasis

  Cancer Research · 2012 · 10.1158/0008-5472.can-11-3863

• A diagnostic gene profile for molecular subtyping of breast cancer associated with treatment response

  Breast Cancer Research and Treatment · 2011 · 10.1007/s10549-011-1683-z

• A Pumilio-induced RNA structure switch in p27-3′ UTR controls miR-221 and miR-222 accessibility

  Nature Cell Biology · 2010 · 10.1038/ncb2105

• Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7–RILP–p150Glued and late endosome positioning

  The Journal of Cell Biology · 2009 · 10.1083/jcb.200811005

• Activation of endosomal dynein motors by stepwise assembly of Rab7–RILP–p150Glued, ORP1L, and the receptor βlll spectrin

  The Journal of Cell Biology · 2007 · 10.1083/jcb.200606077

• Phosphatidylinositol 4-Kinaseβ Is Critical for Functional Association of rab11 with the Golgi Complex

  Molecular Biology of the Cell · 2004 · 10.1091/mbc.e03-12-0862

Current projects

No projects listed.