Will Spooren

Research interests

Publications

• Patients with autism spectrum disorders display reproducible functional connectivity alterations

  Science Translational Medicine · 2019 · https://doi.org/10.1126/scitranslmed.aat9223

• Altered Connectivity Between Cerebellum, Visual, and Sensory-Motor Networks in Autism Spectrum Disorder: Results from the EU-AIMS Longitudinal European Autism Project

  Biological Psychiatry Cognitive Neuroscience and Neuroimaging · 2018 · https://doi.org/10.1016/j.bpsc.2018.11.010

• Altered Connectivity Between Cerebellum, Visual, and Sensory-Motor Networks in Autism Spectrum Disorder: Results from the EU-AIMS Longitudinal European Autism Project

  Biological Psychiatry Cognitive Neuroscience and Neuroimaging · 2018 · https://doi.org/10.1016/j.bpsc.2018.11.010

• Glutamate and GABA in autism spectrum disorder—a translational magnetic resonance spectroscopy study in man and rodent models

  Translational Psychiatry · 2018 · https://doi.org/10.1038/s41398-018-0155-1

• Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome

  Nature Reviews Drug Discovery · 2017 · https://doi.org/10.1038/nrd.2017.221

• The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders

  Molecular Autism · 2017 · https://doi.org/10.1186/s13229-017-0146-8

• The EU-AIMS Longitudinal European Autism Project (LEAP): clinical characterisation

  Molecular Autism · 2017 · https://doi.org/10.1186/s13229-017-0145-9

• Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice

  Neuron · 2012 · https://doi.org/10.1016/j.neuron.2012.03.009

• Shared Synaptic Pathophysiology in Syndromic and Nonsyndromic Rodent Models of Autism

  Science · 2012 · https://doi.org/10.1126/science.1224159

• Age-dependent cognitive decline and amygdala pathology in α-synuclein transgenic mice

  Neurobiology of Aging · 2006 · https://doi.org/10.1016/j.neurobiolaging.2006.06.013

• Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity

  Journal of Pharmacology and Experimental Therapeutics · 2005 · https://doi.org/10.1124/jpet.105.089839

• Behavioral Characterization of the Novel GABAB Receptor-Positive Modulator GS39783 (N,N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): Anxiolytic-Like Activity without Side Effects Associated with Baclofen or Benzodiazepines

  Journal of Pharmacology and Experimental Therapeutics · 2004 · https://doi.org/10.1124/jpet.104.066753

• Insight into the function of Group I and Group II metabotropic glutamate (mGlu) receptors: behavioural characterization and implications for the treatment of CNS disorders

  Behavioural Pharmacology · 2003 · https://doi.org/10.1097/01.fbp.0000081783.35927.8f

• Misfolded proteinase K–resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies

  Journal of Clinical Investigation · 2002 · https://doi.org/10.1172/jci200215777

• Misfolded proteinase K–resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies

  Journal of Clinical Investigation · 2002 · https://doi.org/10.1172/jci15777

• Hyperphosphorylation and insolubility of α‐synuclein in transgenic mouse oligodendrocytes

  EMBO Reports · 2002 · https://doi.org/10.1093/embo-reports/kvf109

• Chronic But Not Acute Treatment with a Metabotropic Glutamate 5 Receptor Antagonist Reverses the Akinetic Deficits in a Rat Model of Parkinsonism

  Journal of Neuroscience · 2002 · https://doi.org/10.1523/jneurosci.22-13-05669.2002

• Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function

  Neuropharmacology · 2001 · https://doi.org/10.1016/s0028-3908(00)00113-1

• Epilepsy, Hyperalgesia, Impaired Memory, and Loss of Pre- and Postsynaptic GABAB Responses in Mice Lacking GABAB(1)

  Neuron · 2001 · https://doi.org/10.1016/s0896-6273(01)00345-2

• Novel allosteric antagonists shed light on mglu5 receptors and CNS disorders

  Trends in Pharmacological Sciences · 2001 · https://doi.org/10.1016/s0165-6147(00)01694-1

• Anxiolytic-Like Effects of the Prototypical Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)pyridine in Rodents

  Journal of Pharmacology and Experimental Therapeutics · 2000 · https://doi.org/10.1016/s0022-3565(24)39029-9

• Neuropathology in mice expressing human alpha-synuclein

  PubMed · 2000 · https://doi.org/10.5451/unibas-ep2767

• Early and Selective Loss of Neuromuscular Synapse Subtypes with Low Sprouting Competence in Motoneuron Diseases

  Journal of Neuroscience · 2000 · https://doi.org/10.1523/jneurosci.20-07-02534.2000

• Neuropathology in Mice Expressing Human α-Synuclein

  Journal of Neuroscience · 2000 · https://doi.org/10.1523/jneurosci.20-16-06021.2000

• Different Outcomes of the Wilcoxon—Mann—Whitney Test from Different Statistics Packages

  The American Statistician · 2000 · https://doi.org/10.1080/00031305.2000.10474513

Current projects

No projects listed.