T. Krojer

Research interests

Publications

• Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

  Science Advances · 2021 · 10.1126/sciadv.abf8711

• Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-020-18709-w

• Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

  Journal of the American Chemical Society · 2019 · https://doi.org/10.1021/jacs.9b02822

• TheXChemExplorergraphical workflow tool for routine or large-scale protein–ligand structure determination

  Acta Crystallographica Section D Structural Biology · 2017 · 10.1107/s2059798316020234

• Gentle, fast and effective crystal soaking by acoustic dispensing

  Acta Crystallographica Section D Structural Biology · 2017 · 10.1107/s205979831700331x

• A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density

  Nature Communications · 2017 · https://doi.org/10.1038/ncomms15123

• Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin

  Cell Reports · 2016 · 10.1016/j.celrep.2016.11.014

• 8-Substituted Pyrido[3,4- d ]pyrimidin-4(3 H )-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

  Journal of Medicinal Chemistry · 2016 · 10.1021/acs.jmedchem.5b01635

• Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design

  Human Molecular Genetics · 2015 · 10.1093/hmg/ddv280

• A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain

  Chemical Science · 2015 · 10.1039/c5sc03115j

• Ribosomal oxygenases are structurally conserved from prokaryotes to humans

  Nature · 2014 · 10.1038/nature13263

• 5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation

  Chemical Science · 2013 · 10.1039/c3sc51122g

• Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases

  Journal of Biological Chemistry · 2013 · https://doi.org/10.1074/jbc.m112.437996

• Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

  Journal of Medicinal Chemistry · 2012 · 10.1021/jm300677j

• Substrate-induced remodeling of the active site regulates human HTRA1 activity

  Nature Structural & Molecular Biology · 2011 · 10.1038/nsmb.2013

• Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

  Proceedings of the National Academy of Sciences · 2011 · 10.1073/pnas.1101262108

• HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues

  Nature Structural & Molecular Biology · 2010 · 10.1038/nsmb.1840

• Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6

  Journal of Molecular Biology · 2010 · 10.1016/j.jmb.2010.05.054

• Structural and Mechanistic Studies on γ-Butyrobetaine Hydroxylase

  Chemistry & Biology · 2010 · 10.1016/j.chembiol.2010.09.016

• Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins

  Proceedings of the National Academy of Sciences · 2008 · 10.1073/pnas.0803392105

• Structural basis for the regulated protease and chaperone function of DegP

  Nature · 2008 · 10.1038/nature07004

• Regulation of the σE stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress

  Genes & Development · 2007 · 10.1101/gad.445307

• Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine

  Nature · 2002 · 10.1038/416455a

Current projects

No projects listed.