O. Gileadi

Research interests

Publications

• Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase

  Nature Communications · 2021 · https://doi.org/10.1038/s41467-021-25166-6

• Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72

  eLife · 2019 · https://doi.org/10.7554/elife.48363

• Progress towards a public chemogenomic set for protein kinases and a call for contributions

  PLoS ONE · 2017 · https://doi.org/10.1371/journal.pone.0181585

• Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair

  Molecular Cell · 2016 · https://doi.org/10.1016/j.molcel.2016.09.032

• Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers

  Antimicrobial Agents and Chemotherapy · 2015 · https://doi.org/10.1128/aac.01335-15

• Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

  Proceedings of the National Academy of Sciences · 2013 · https://doi.org/10.1073/pnas.1217042110

• Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases

  Journal of Biological Chemistry · 2013 · https://doi.org/10.1074/jbc.m112.437996

• A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells

  Chemistry & Biology · 2013 · https://doi.org/10.1016/j.chembiol.2012.10.016

• Human SNM1A and XPF–ERCC1 collaborate to initiate DNA interstrand cross-link repair

  Genes & Development · 2011 · https://doi.org/10.1101/gad.15699211

• Identification of Macrodomain Proteins as Novel O-Acetyl-ADP-ribose Deacetylases

  Journal of Biological Chemistry · 2011 · https://doi.org/10.1074/jbc.m110.206771

• High-throughput production of human proteins for crystallization: The SGC experience

  Journal of Structural Biology · 2010 · https://doi.org/10.1016/j.jsb.2010.06.008

• Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study

  Protein Expression and Purification · 2008 · https://doi.org/10.1016/j.pep.2008.01.008

• Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

  Nature · 2007 · https://doi.org/10.1038/nature05971

• Reversible Sequestration of Active Site Cysteines in a 2Fe-2S-bridged Dimer Provides a Mechanism for Glutaredoxin 2 Regulation in Human Mitochondria

  Journal of Biological Chemistry · 2006 · https://doi.org/10.1074/jbc.m608179200

• Scanning electron microscopy of cells and tissues under fully hydrated conditions

  Proceedings of the National Academy of Sciences · 2004 · https://doi.org/10.1073/pnas.0400088101

• An Unusual Eukaryotic Protein Phosphatase Required for Transcription by RNA Polymerase II and CTD Dephosphorylation in S. cerevisiae

  Molecular Cell · 1999 · https://doi.org/10.1016/s1097-2765(00)80187-2

• CTD kinase associated with yeast RNA polymerase II initiation factor b

  Cell · 1991 · https://doi.org/10.1016/0092-8674(91)90298-d

Current projects

No projects listed.