Bruce J. Brew

Research interests

Publications

• Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing

  JAMA Neurology · 2018 · 10.1001/jamaneurol.2018.0463

• Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression

  Scientific Reports · 2017 · https://doi.org/10.1038/srep41473

• Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases

  Neuropharmacology · 2016 · 10.1016/j.neuropharm.2016.03.024

• Interferon-γ Regulates the Proliferation and Differentiation of Mesenchymal Stem Cells via Activation of Indoleamine 2,3 Dioxygenase (IDO)

  PLoS ONE · 2011 · 10.1371/journal.pone.0014698

• Progressive multifocal leukoencephalopathy and other forms of JC virus disease

  Nature Reviews Neurology · 2010 · 10.1038/nrneurol.2010.164

• Extensive astrocyte infection is prominent in human immunodeficiency virus–associated dementia

  Annals of Neurology · 2009 · 10.1002/ana.21697

• Mechanism for Quinolinic Acid Cytotoxicity in Human Astrocytes and Neurons

  Neurotoxicity Research · 2009 · 10.1007/s12640-009-9051-z

• The Excitotoxin Quinolinic Acid Induces Tau Phosphorylation in Human Neurons

  PLoS ONE · 2009 · 10.1371/journal.pone.0006344

• Validity of the CogState Brief Battery: Relationship to Standardized Tests and Sensitivity to Cognitive Impairment in Mild Traumatic Brain Injury, Schizophrenia, and AIDS Dementia Complex

  Archives of Clinical Neuropsychology · 2009 · https://doi.org/10.1093/arclin/acp010

• Characterization of the Kynurenine Pathway in Human Neurons

  Journal of Neuroscience · 2007 · 10.1523/jneurosci.4101-07.2007

• Updated research nosology for HIV-associated neurocognitive disorders

  Neurology · 2007 · https://doi.org/10.1212/01.wnl.0000287431.88658.8b

• Indoleamine 2,3 dioxygenase and quinolinic acid Immunoreactivity in Alzheimer's disease hippocampus

  Neuropathology and Applied Neurobiology · 2005 · 10.1111/j.1365-2990.2005.00655.x

• Neurological complications of HIV infection

  The Lancet Neurology · 2005 · 10.1016/s1474-4422(05)70165-4

• Expression of indoleamine 2,3‐dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons

  Glia · 2004 · 10.1002/glia.20090

• Prevalence and pattern of neuropsychological impairment in human immunodeficiency virus–infected/acquired immunodeficiency syndrome (HIV/AIDS) patients across pre- and post-highly active antiretroviral therapy eras: A combined study of two cohorts Clinical Report

  Journal of NeuroVirology · 2004 · https://doi.org/10.1080/13550280490521078

• Marked improvement in survival following AIDS dementia complex in the era of highly active antiretroviral therapy

  AIDS · 2003 · 10.1097/00002030-200307040-00015

• Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification

  Journal of Leukocyte Biology · 2003 · 10.1189/jlb.0303114

• Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection

  Journal of Neurochemistry · 2001 · 10.1046/j.1471-4159.2001.00498.x

• Changes to AIDS dementia complex in the era of highly active antiretroviral therapy

  AIDS · 1999 · https://doi.org/10.1097/00002030-199907090-00015

• Levels of Human Immunodeficiency Virus Type 1 RNA in Cerebrospinal Fluid Correlate with AIDS Dementia Stage

  The Journal of Infectious Diseases · 1997 · 10.1086/514001

• AIDS dementia complex and HIV‐1 brain infection: Clinical‐virological correlations

  Annals of Neurology · 1995 · 10.1002/ana.410380404

• Low-Dose Trimethoprim-Sulfamethoxazole Prophylaxis for Toxoplasmic Encephalitis in Patients with AIDS

  Annals of Internal Medicine · 1992 · 10.7326/0003-4819-117-2-106

• Quinolinic acid in cerebrospinal fluid and serum in HIV‐1 Infection: Relationship to clinical and neurological status

  Annals of Neurology · 1991 · https://doi.org/10.1002/ana.410290215

• The AIDS Dementia Complex

  The Journal of Infectious Diseases · 1988 · https://doi.org/10.1093/infdis/158.5.1079

• The Brain in AIDS: Central Nervous System HIV-1 Infection and AIDS Dementia Complex

  Science · 1988 · https://doi.org/10.1126/science.3277272

Current projects

No projects listed.