Markus Heilig

Research interests

Publications

• Addiction as a brain disease revised: why it still matters, and the need for consilience

  Neuropsychopharmacology · 2021 · 10.1038/s41386-020-00950-y

• Alcohol use disorders

  The Lancet · 2019 · https://doi.org/10.1016/s0140-6736(19)31775-1

• A molecular mechanism for choosing alcohol over an alternative reward

  Science · 2018 · 10.1126/science.aao1157

• Time to connect: bringing social context into addiction neuroscience

  Nature reviews. Neuroscience · 2016 · 10.1038/nrn.2016.67

• Corticosteroid-Dependent Plasticity Mediates Compulsive Alcohol Drinking in Rats

  Journal of Neuroscience · 2012 · 10.1523/jneurosci.0069-12.2012

• Pharmacogenetic approaches to the treatment of alcohol addiction

  Nature reviews. Neuroscience · 2011 · 10.1038/nrn3110

• REVIEW: Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked?

  Addiction Biology · 2010 · 10.1111/j.1369-1600.2009.00194.x

• Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse

  Pharmacology & Therapeutics · 2010 · 10.1016/j.pharmthera.2010.09.007

• Requirement of central ghrelin signaling for alcohol reward

  Proceedings of the National Academy of Sciences · 2009 · 10.1073/pnas.0812809106

• A key role for corticotropin-releasing factor in alcohol dependence

  Trends in Neurosciences · 2007 · https://doi.org/10.1016/j.tins.2007.06.006

• Upregulation of Voluntary Alcohol Intake, Behavioral Sensitivity to Stress, and Amygdala Crhr1 Expression Following a History of Dependence

  Biological Psychiatry · 2007 · 10.1016/j.biopsych.2007.01.010

• 3-(4-Chloro-2-Morpholin-4-yl-Thiazol-5-yl)-8-(1-Ethylpropyl)-2,6-Dimethyl-Imidazo[1,2-b]Pyridazine: A Novel Brain-Penetrant, Orally Available Corticotropin-Releasing Factor Receptor 1 Antagonist with Efficacy in Animal Models of Alcoholism

  Journal of Neuroscience · 2007 · 10.1523/jneurosci.4985-06.2007

• Pharmacological treatment of alcohol dependence: Target symptoms and target mechanisms

  Pharmacology & Therapeutics · 2006 · 10.1016/j.pharmthera.2006.02.001

• Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress

  Proceedings of the National Academy of Sciences · 2006 · 10.1073/pnas.0604419103

• The NPY system in stress, anxiety and depression

  Neuropeptides · 2004 · https://doi.org/10.1016/j.npep.2004.05.002

• 1-year retention and social function after buprenorphine-assisted relapse prevention treatment for heroin dependence in Sweden: a randomised, placebo-controlled trial

  The Lancet · 2003 · https://doi.org/10.1016/s0140-6736(03)12600-1

• Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders

  Trends in Pharmacological Sciences · 2003 · 10.1016/j.tips.2003.09.011

• Long‐lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol

  The FASEB Journal · 2002 · 10.1096/fj.01-0593com

• Genetic polymorphism of alcohol dehydrogenase in europeans: The ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1

  Hepatology · 2000 · 10.1053/he.2000.5978

• Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression

  Proceedings of the National Academy of Sciences · 2000 · 10.1073/pnas.220232997

• Corticotropin-releasing factor and neuropeptide y: role in emotional integration

  Trends in Neurosciences · 1994 · 10.1016/0166-2236(94)90079-5

• Anxiolytic-Like Action of Neuropeptide Y: Mediation by Y1 Receptors in Amygdala, and Dissociation from Food Intake Effects

  Neuropsychopharmacology · 1993 · 10.1038/npp.1993.35

• Modulation of Anxiety and Neuropeptide Y-Y1 Receptors by Antisense Oligodeoxynucleotides

  Science · 1993 · https://doi.org/10.1126/science.8380941

• Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models

  Psychopharmacology · 1989 · 10.1007/bf00441953

• Neuropeptide Y (NPY) in the area of the hypothalamic paraventricular nucleus activates the pituitary-adrenocortical axis in the rat

  Brain Research · 1987 · 10.1016/0006-8993(87)90176-4

Current projects

No projects listed.