Yuichi Sugiyama

Research interests

Publications

• Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

  Archives of Toxicology · 2013 · https://doi.org/10.1007/s00204-013-1078-5

• Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption

  Biopharmaceutics & Drug Disposition · 2012 · 10.1002/bdd.1823

• Involvement of Multiple Transporters in the Hepatobiliary Transport of Rosuvastatin

  Drug Metabolism and Disposition · 2008 · 10.1124/dmd.108.021410

• Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans

  Journal of Pharmacology and Experimental Therapeutics · 2008 · 10.1124/jpet.108.146647

• DRUG-DRUG INTERACTION BETWEEN PITAVASTATIN AND VARIOUS DRUGS VIA OATP1B1

  Drug Metabolism and Disposition · 2006 · 10.1124/dmd.106.009290

• Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: Drug–drug interactions and interindividual differences in transporter and metabolic enzyme functions

  Pharmacology & Therapeutics · 2006 · https://doi.org/10.1016/j.pharmthera.2006.03.003

• Transporters as a determinant of drug clearance and tissue distribution

  European Journal of Pharmaceutical Sciences · 2006 · 10.1016/j.ejps.2005.12.003

• EVALUATION OF DRUG-DRUG INTERACTION IN THE HEPATOBILIARY AND RENAL TRANSPORT OF DRUGS

  The Annual Review of Pharmacology and Toxicology · 2004 · 10.1146/annurev.pharmtox.44.101802.121444

• Gemfibrozil and Its Glucuronide Inhibit the Organic Anion Transporting Polypeptide 2 (OATP2/OATP1B1:SLC21A6)-Mediated Hepatic Uptake and CYP2C8-Mediated Metabolism of Cerivastatin: Analysis of the Mechanism of the Clinically Relevant Drug-Drug Interaction between Cerivastatin and Gemfibrozil

  Journal of Pharmacology and Experimental Therapeutics · 2004 · 10.1124/jpet.104.068536

• Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the Hepatic Uptake of Pitavastatin in Humans

  Journal of Pharmacology and Experimental Therapeutics · 2004 · 10.1124/jpet.104.068056

• ABCG2 Transports Sulfated Conjugates of Steroids and Xenobiotics

  Journal of Biological Chemistry · 2003 · 10.1074/jbc.m212399200

• Inhibition of Transporter-Mediated Hepatic Uptake as a Mechanism for Drug-Drug Interaction between Cerivastatin and Cyclosporin A

  Journal of Pharmacology and Experimental Therapeutics · 2003 · 10.1124/jpet.102.041921

• Basin‐centered asperities in great subduction zone earthquakes: A link between slip, subsidence, and subduction erosion?

  Journal of Geophysical Research Atmospheres · 2003 · 10.1029/2002jb002072

• Characterization of uremic toxin transport by organic anion transporters in the kidney

  Kidney International · 2003 · https://doi.org/10.1111/j.1523-1755.2004.00354.x

• Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice.

  PubMed · 2003

• Impact of Drug Transporter Studies on Drug Discovery and Development

  Pharmacological Reviews · 2003 · 10.1124/pr.55.3.1

• Involvement of Organic Cation Transporter 1 in Hepatic and Intestinal Distribution of Metformin

  Journal of Pharmacology and Experimental Therapeutics · 2002 · 10.1124/jpet.102.034140

• Long-circulating poly(ethylene glycol)–poly(d,l-lactide) block copolymer micelles with modulated surface charge

  Journal of Controlled Release · 2001 · 10.1016/s0168-3659(01)00451-5

• ATP-dependent Transport of Bile Salts by Rat Multidrug Resistance-associated Protein 3 (Mrp3)

  Journal of Biological Chemistry · 2000 · 10.1074/jbc.275.4.2905

• Molecular Cloning and Characterization of Multispecific Organic Anion Transporter 4 Expressed in the Placenta

  Journal of Biological Chemistry · 2000 · 10.1074/jbc.275.6.4507

• Molecular Cloning and Characterization of a New Multispecific Organic Anion Transporter from Rat Brain

  Journal of Biological Chemistry · 1999 · 10.1074/jbc.274.19.13675

• Characterization of the Transport Properties of Cloned Rat Multidrug Resistance-associated Protein 3 (MRP3)

  Journal of Biological Chemistry · 1999 · 10.1074/jbc.274.21.15181

• Prediction of Pharmacokinetic Alterations Caused by Drug-Drug Interactions: Metabolic Interaction in the Liver

  Pharmacological Reviews · 1998 · https://doi.org/10.1016/s0031-6997(24)01372-3

• Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

  Pharmacology & Therapeutics · 1997 · 10.1016/s0163-7258(96)00184-2

• Typing hepatitis C virus by polymerase chain reaction with type-specific primers: application to clinical surveys and tracing infectious sources

  Journal of General Virology · 1992 · https://doi.org/10.1099/0022-1317-73-3-673

• Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human carrier: comparison with reported isolates for conserved and divergent regions

  Journal of General Virology · 1991 · 10.1099/0022-1317-72-11-2697

Current projects

No projects listed.