Piero Marchetti

Research interests

Publications

• Targeting GLP-1 receptor trafficking to improve agonist efficacy

  Nature Communications · 2018 · 10.1038/s41467-018-03941-2

• Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

  Cell Metabolism · 2016 · 10.1016/j.cmet.2016.06.020

• Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

  The Journal of Clinical Endocrinology & Metabolism · 2015 · 10.1210/jc.2015-2860

• Proceedings From an International Consensus Meeting on Posttransplantation Diabetes Mellitus: Recommendations and Future Directions

  American Journal of Transplantation · 2014 · 10.1111/ajt.12850

• RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate

  Diabetes · 2013 · 10.2337/db13-1383

• Encapsulated islets for diabetes therapy: History, current progress, and critical issues requiring solution

  Advanced Drug Delivery Reviews · 2013 · 10.1016/j.addr.2013.07.018

• The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

  PLoS Genetics · 2012 · 10.1371/journal.pgen.1002552

• DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

  The EMBO Journal · 2012 · 10.1038/emboj.2011.503

• Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes

  PLoS ONE · 2010 · 10.1371/journal.pone.0011499

• The emerging role of autophagy in the pathophysiology of diabetes mellitus

  Autophagy · 2010 · https://doi.org/10.4161/auto.7.1.13044

• Autophagy in human type 2 diabetes pancreatic beta cells

  Diabetologia · 2009 · 10.1007/s00125-009-1347-2

• Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion

  Diabetologia · 2008 · 10.1007/s00125-007-0916-5

• Initiation and execution of lipotoxic ER stress in pancreatic β-cells

  Journal of Cell Science · 2008 · 10.1242/jcs.026062

• Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

  Nature Genetics · 2008 · https://doi.org/10.1038/ng.288

• Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients

  Proceedings of the National Academy of Sciences · 2007 · 10.1073/pnas.0700442104

• Results of an International, Randomized Trial Comparing Glucose Metabolism Disorders and Outcome with Cyclosporine Versus Tacrolimus

  American Journal of Transplantation · 2007 · https://doi.org/10.1111/j.1600-6143.2007.01749.x

• The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients

  Diabetologia · 2007 · 10.1007/s00125-007-0816-8

• Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

  Journal of Clinical Investigation · 2007 · https://doi.org/10.1172/jci30706

• Functional and Molecular Defects of Pancreatic Islets in Human Type 2 Diabetes

  Diabetes · 2005 · 10.2337/diabetes.54.3.727

• Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients

  Diabetologia · 2005 · 10.1007/s00125-004-1627-9

• Pancreatic Islets from Type 2 Diabetic Patients Have Functional Defects and Increased Apoptosis That Are Ameliorated by Metformin

  The Journal of Clinical Endocrinology & Metabolism · 2004 · 10.1210/jc.2004-0150

• NEW-ONSET DIABETES AFTER TRANSPLANTATION: 2003 INTERNATIONAL CONSENSUS GUIDELINES1

  Transplantation · 2003 · https://doi.org/10.1097/01.tp.0000069952.49242.3e

• Prolonged Exposure to Free Fatty Acids Has Cytostatic and Pro-Apoptotic Effects on Human Pancreatic Islets

  Diabetes · 2002 · https://doi.org/10.2337/diabetes.51.5.1437

• High Glucose Causes Apoptosis in Cultured Human Pancreatic Islets of Langerhans

  Diabetes · 2001 · 10.2337/diabetes.50.6.1290

• Insulin Independence After Islet Transplantation Into Type I Diabetic Patient

  Diabetes · 1990 · 10.2337/diab.39.4.515

Current projects

No projects listed.