Loreto Gesualdo

Research interests

Publications

• Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy

  Nature Genetics · 2023 · https://doi.org/10.1038/s41588-023-01422-x

• Rituximab or Cyclophosphamide in the Treatment of Membranous Nephropathy: The RI-CYCLO Randomized Trial

  Journal of the American Society of Nephrology · 2021 · 10.1681/asn.2020071091

• The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis

  Nature Communications · 2020 · 10.1038/s41467-020-15383-w

• Acute kidney injury in SARS-CoV-2 infected patients

  Critical Care · 2020 · 10.1186/s13054-020-02872-z

• The Use of Immune Checkpoint Inhibitors in Oncology and the Occurrence of AKI: Where Do We Stand?

  Frontiers in Immunology · 2020 · 10.3389/fimmu.2020.574271

• Identification of the Uric Acid Thresholds Predicting an Increased Total and Cardiovascular Mortality Over 20 Years

  Hypertension · 2019 · https://doi.org/10.1161/hypertensionaha.119.13643

• The copy number variation landscape of congenital anomalies of the kidney and urinary tract

  Nature Genetics · 2018 · 10.1038/s41588-018-0281-y

• DUET: A Phase 2 Study Evaluating the Efficacy and Safety of Sparsentan in Patients with FSGS

  Journal of the American Society of Nephrology · 2018 · https://doi.org/10.1681/asn.2018010091

• Recent advances in the pathogenetic mechanisms of sepsis-associated acute kidney injury

  Journal of Nephrology · 2017 · 10.1007/s40620-017-0452-4

• Renal biopsy in patients with diabetes: a pooled meta-analysis of 48 studies

  Nephrology Dialysis Transplantation · 2016 · 10.1093/ndt/gfw070

• Brain neural synchronization and functional coupling in Alzheimer's disease as revealed by resting state EEG rhythms

  International Journal of Psychophysiology · 2015 · 10.1016/j.ijpsycho.2015.02.008

• The MEST score provides earlier risk prediction in lgA nephropathy

  Kidney International · 2015 · 10.1038/ki.2015.322

• Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

  Nature Genetics · 2014 · https://doi.org/10.1038/ng.3118

• Validation of the Oxford classification of IgA nephropathy in cohorts with different presentations and treatments

  Kidney International · 2014 · 10.1038/ki.2014.63

• Microbiota and Metabolome Associated with Immunoglobulin A Nephropathy (IgAN)

  PLoS ONE · 2014 · 10.1371/journal.pone.0099006

• Geographic Differences in Genetic Susceptibility to IgA Nephropathy: GWAS Replication Study and Geospatial Risk Analysis

  PLoS Genetics · 2012 · https://doi.org/10.1371/journal.pgen.1002765

• Copy-Number Disorders Are a Common Cause of Congenital Kidney Malformations

  The American Journal of Human Genetics · 2012 · 10.1016/j.ajhg.2012.10.007

• Genome-wide association study identifies susceptibility loci for IgA nephropathy

  Nature Genetics · 2011 · https://doi.org/10.1038/ng.787

• Ketohexokinase-Dependent Metabolism of Fructose Induces Proinflammatory Mediators in Proximal Tubular Cells

  Journal of the American Society of Nephrology · 2009 · 10.1681/asn.2008060576

• Essential but differential role for CXCR4 and CXCR7 in the therapeutic homingof human renal progenitor cells

  The Journal of Experimental Medicine · 2008 · 10.1084/jem.20071903

• Regenerative Potential of Embryonic Renal Multipotent Progenitors in Acute Renal Failure

  Journal of the American Society of Nephrology · 2007 · 10.1681/asn.2007020210

• Isolation and Characterization of Multipotent Progenitor Cells from the Bowman’s Capsule of Adult Human Kidneys

  Journal of the American Society of Nephrology · 2006 · https://doi.org/10.1681/asn.2006010089

• Pathogenetic Mechanisms of Diabetic Nephropathy

  Journal of the American Society of Nephrology · 2005 · https://doi.org/10.1681/asn.2004110970

• Sirolimus for Kaposi's Sarcoma in Renal-Transplant Recipients

  New England Journal of Medicine · 2005 · https://doi.org/10.1056/nejmoa042831

• Predictors of bleeding complications in percutaneous ultrasound-guided renal biopsy

  Kidney International · 2004 · 10.1111/j.1523-1755.2004.00922.x

• Disease-associated Bias in T Helper Type 1 (Th1)/Th2 CD4+ T Cell Responses Against MAGE-6 in HLA-DRB10401+ Patients With Renal Cell Carcinoma or Melanoma

  The Journal of Experimental Medicine · 2002 · 10.1084/jem.20012142

• Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells.

  Journal of Clinical Investigation · 1989 · 10.1172/jci114363

Current projects

No projects listed.