Dominique Schols

Research interests

Publications

• A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate

  Nature · 2020 · https://doi.org/10.1038/s41586-020-3035-9

• STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

  Nature Communications · 2020 · 10.1038/s41467-020-19684-y

• Chloro-1,4-dimethyl-9H-carbazole Derivatives Displaying Anti-HIV Activity

  Molecules · 2018 · 10.3390/molecules23020286

• The Viral Polymerase Inhibitor 7-Deaza-2’-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model

  PLoS neglected tropical diseases · 2016 · 10.1371/journal.pntd.0004695

• CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells

  Proceedings of the National Academy of Sciences · 2010 · https://doi.org/10.1073/pnas.1012865107

• CXCL12-CXCR4 Axis in Angiogenesis, Metastasis and Stem Cell Mobilization

  Current Pharmaceutical Design · 2010 · 10.2174/138161210794455003

• Safety, Pharmacokinetics, and Antiviral Activity of AMD3100, a Selective CXCR4 Receptor Inhibitor, in HIV-1 Infection

  JAIDS Journal of Acquired Immune Deficiency Syndromes · 2004 · 10.1097/01.qai.0000137371.80695.ef

• Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4

  FEBS Letters · 2002 · 10.1016/s0014-5793(02)03143-5

• AMD3100, a CxCR4 Antagonist, Attenuates Allergic Lung Inflammation and Airway Hyperreactivity

  American Journal Of Pathology · 2002 · 10.1016/s0002-9440(10)62562-x

• CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity

  Nature Neuroscience · 2001 · https://doi.org/10.1038/89490

• AMD3100, a Potent and Specific Antagonist of the Stromal Cell-Derived Factor-1 Chemokine Receptor CXCR4, Inhibits Autoimmune Joint Inflammation in IFN-γ Receptor-Deficient Mice

  The Journal of Immunology · 2001 · https://doi.org/10.4049/jimmunol.167.8.4686

• Macrophage Tropism of Human Immunodeficiency Virus Type 1 Isolates from Brain and Lymphoid Tissues Predicts Neurotropism Independent of Coreceptor Specificity

  Journal of Virology · 2001 · https://doi.org/10.1128/jvi.75.21.10073-10089.2001

• AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor

  Nature Medicine · 1998 · https://doi.org/10.1038/nm0198-072

• Amino-terminal Truncation of Chemokines by CD26/Dipeptidyl-peptidase IV

  Journal of Biological Chemistry · 1998 · https://doi.org/10.1074/jbc.273.13.7222

• Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor Fusin/CXCR-4

  Antiviral Research · 1997 · 10.1016/s0166-3542(97)00025-9

• Inhibition of T-tropic HIV Strains by Selective Antagonization of the Chemokine Receptor CXCR4

  The Journal of Experimental Medicine · 1997 · https://doi.org/10.1084/jem.186.8.1383

• Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase.

  Proceedings of the National Academy of Sciences · 1993 · https://doi.org/10.1073/pnas.90.5.1711

• Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine

  Antimicrobial Agents and Chemotherapy · 1993 · https://doi.org/10.1128/aac.37.2.332

• Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event.

  Proceedings of the National Academy of Sciences · 1992 · https://doi.org/10.1073/pnas.89.12.5286

• The mannose-specific plant lectins from Cymbidium hybrid and Epipactis helleborine and the (N-acetylglucosamine)n-specific plant lectin from Urtica dioica are potent and selective inhibitors of human immunodeficiency virus and cytomegalovirus replication in vitro

  Antiviral Research · 1992 · https://doi.org/10.1016/0166-3542(92)90038-7

• Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro

  Antimicrobial Agents and Chemotherapy · 1991 · https://doi.org/10.1128/aac.35.3.410

• Dextran sulfate and other polyanionic anti-HIV compounds specifically interact with the viral gp120 glycoprotein expressed by T-cells persistently infected with HIV-1

  Virology · 1990 · 10.1016/0042-6822(90)90440-3

• Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

  Nature · 1990 · https://doi.org/10.1038/343470a0

• Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative

  Biochemical and Biophysical Research Communications · 1989 · https://doi.org/10.1016/0006-291x(89)92756-3

• Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

  Journal of Virological Methods · 1988 · https://doi.org/10.1016/0166-0934(88)90134-6

• Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents

  Antimicrobial Agents and Chemotherapy · 1988 · https://doi.org/10.1128/aac.32.7.1025

Current projects

No projects listed.