Javier Crespo

Research interests

Publications

• Low-to-moderate alcohol consumption is associated with increased fibrosis in individuals with metabolic dysfunction-associated steatotic liver disease

  Journal of Hepatology · 2024 · 10.1016/j.jhep.2024.06.036

• Adjusted estimate of the prevalence of hepatitis delta virus in 25 countries and territories

  Journal of Hepatology · 2023 · https://doi.org/10.1016/j.jhep.2023.10.043

• Biomarkers for staging fibrosis and non-alcoholic steatohepatitis in non-alcoholic fatty liver disease (the LITMUS project): a comparative diagnostic accuracy study

  ˜The œLancet. Gastroenterology & hepatology · 2023 · 10.1016/s2468-1253(23)00017-1

• Global change in hepatitis C virus prevalence and cascade of care between 2015 and 2020: a modelling study

  ˜The œLancet. Gastroenterology & hepatology · 2022 · https://doi.org/10.1016/s2468-1253(21)00472-6

• Disease burden and economic impact of diagnosed non‐alcoholic steatohepatitis in five European countries in 2018: A cost‐of‐illness analysis

  Liver International · 2021 · 10.1111/liv.14825

• Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry

  Journal of Hepatology · 2021 · 10.1016/j.jhep.2021.01.029

• Measurement and clinical usefulness of bilirubin in liver disease

  Advances in Laboratory Medicine / Avances en Medicina de Laboratorio · 2021 · 10.1515/almed-2021-0047

• Measurement and clinical usefulness of bilirubin in liver disease

  Advances in Laboratory Medicine / Avances en Medicina de Laboratorio · 2021 · 10.1515/almed-2021-0047

• Disease burden and economic impact of diagnosed non‐alcoholic steatohepatitis in five European countries in 2018: A cost‐of‐illness analysis

  Liver International · 2021 · 10.1111/liv.14825

• Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry

  Journal of Hepatology · 2021 · 10.1016/j.jhep.2021.01.029

• Advancing the global public health agenda for NAFLD: a consensus statement

  Nature Reviews Gastroenterology & Hepatology · 2021 · https://doi.org/10.1038/s41575-021-00523-4

• Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly

  Cell Metabolism · 2020 · 10.1016/j.cmet.2020.01.013

• JNJ-56136379, an HBV Capsid Assembly Modulator, Is Well-Tolerated and Has Antiviral Activity in a Phase 1 Study of Patients With Chronic Infection

  Gastroenterology · 2020 · 10.1053/j.gastro.2020.04.036

• JNJ-56136379, an HBV Capsid Assembly Modulator, Is Well-Tolerated and Has Antiviral Activity in a Phase 1 Study of Patients With Chronic Infection

  Gastroenterology · 2020 · 10.1053/j.gastro.2020.04.036

• Vitamin D Status in Hospitalized Patients with SARS-CoV-2 Infection

  The Journal of Clinical Endocrinology & Metabolism · 2020 · 10.1210/clinem/dgaa733

• Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation

  Nature Communications · 2020 · 10.1038/s41467-020-16991-2

• Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly

  Cell Metabolism · 2020 · 10.1016/j.cmet.2020.01.013

• Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation

  Nature Communications · 2020 · 10.1038/s41467-020-16991-2

• Development and Validation of Hepamet Fibrosis Scoring System–A Simple, Noninvasive Test to Identify Patients With Nonalcoholic Fatty Liver Disease With Advanced Fibrosis

  Clinical Gastroenterology and Hepatology · 2019 · https://doi.org/10.1016/j.cgh.2019.05.051

• Metabolomic‐based noninvasive serum test to diagnose nonalcoholic steatohepatitis: Results from discovery and validation cohorts

  Hepatology Communications · 2018 · https://doi.org/10.1002/hep4.1188

• Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030

  Journal of Hepatology · 2018 · https://doi.org/10.1016/j.jhep.2018.05.036

• Effectiveness, safety and clinical outcomes of direct-acting antiviral therapy in HCV genotype 1 infection: Results from a Spanish real-world cohort

  Journal of Hepatology · 2017 · 10.1016/j.jhep.2017.01.028

• Effectiveness, safety and clinical outcomes of direct-acting antiviral therapy in HCV genotype 1 infection: Results from a Spanish real-world cohort

  Journal of Hepatology · 2017 · 10.1016/j.jhep.2017.01.028

• The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury

  Nature Communications · 2017 · 10.1038/s41467-017-01970-x

• Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis

  Gastroenterology · 2017 · 10.1053/j.gastro.2017.01.015

• The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury

  Nature Communications · 2017 · 10.1038/s41467-017-01970-x

• Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

  Gastroenterology · 2016 · https://doi.org/10.1053/j.gastro.2016.01.038

• Obesity-Dependent Metabolic Signatures Associated with Nonalcoholic Fatty Liver Disease Progression

  Journal of Proteome Research · 2012 · 10.1021/pr201223p

• Risk factors for hepatic encephalopathy in patients with cirrhosis and refractory ascites: relevance of serum sodium concentration

  Liver International · 2010 · 10.1111/j.1478-3231.2010.02293.x

• Risk factors for hepatic encephalopathy in patients with cirrhosis and refractory ascites: relevance of serum sodium concentration

  Liver International · 2010 · 10.1111/j.1478-3231.2010.02293.x

• Lipopolysaccharide-Binding Protein Plasma Levels and Liver TNF-Alpha Gene Expression in Obese Patients: Evidence for the Potential Role of Endotoxin in the Pathogenesis of Non-Alcoholic Steatohepatitis

  Obesity Surgery · 2007 · 10.1007/s11695-007-9243-7

• Peginterferon-Alfa2a Plus Ribavirin for 48 Versus 72 Weeks in Patients With Detectable Hepatitis C Virus RNA at Week 4 of Treatment

  Gastroenterology · 2006 · 10.1053/j.gastro.2006.05.016

• Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2

  Journal of Biological Chemistry · 2003 · https://doi.org/10.1074/jbc.c200673200

• Gene expression of tumor necrosis factor α and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients

  Hepatology · 2001 · https://doi.org/10.1053/jhep.2001.29628

• Prevalence and significance of hepatitis C viremia in chronic active hepatitis B.

  PubMed · 1994

• Prevalence and significance of hepatitis C viremia in chronic active hepatitis B.

  PubMed · 1994

Current projects

No projects listed.