Gabriel Capellá

Research interests

Publications

• Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study

  The Lancet Oncology · 2021 · https://doi.org/10.1016/s1470-2045(21)00189-3

• Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

  Genetics in Medicine · 2019 · https://doi.org/10.1038/s41436-019-0596-9

• Cancer Risks for PMS2 -Associated Lynch Syndrome

  Journal of Clinical Oncology · 2018 · https://doi.org/10.1200/jco.2018.78.4777

• Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database

  Gut · 2017 · https://doi.org/10.1136/gutjnl-2017-314057

• POLE and POLD1 mutations in 529 kindred with familial colorectal cancer and/or polyposis: review of reported cases and recommendations for genetic testing and surveillance

  Genetics in Medicine · 2015 · 10.1038/gim.2015.75

• Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database

  Gut · 2015 · https://doi.org/10.1136/gutjnl-2015-309675

• Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2854

• Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts

  Gut · 2013 · https://doi.org/10.1136/gutjnl-2012-304356

• Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial‐to‐mesenchymal transition

  International Journal of Cancer · 2013 · https://doi.org/10.1002/ijc.28387

• A DNA methylation fingerprint of 1628 human samples

  Genome Research · 2011 · https://doi.org/10.1101/gr.119867.110

• Peutz–Jeghers syndrome: a systematic review and recommendations for management

  Gut · 2010 · https://doi.org/10.1136/gut.2009.198499

• Gene Expression Signature to Improve Prognosis Prediction of Stage II and III Colorectal Cancer

  Journal of Clinical Oncology · 2010 · https://doi.org/10.1200/jco.2010.30.1077

• Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer

  Proceedings of the National Academy of Sciences · 2009 · 10.1073/pnas.0813221106

• The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer

  Genome Research · 2009 · https://doi.org/10.1101/gr.083550.108

• A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function

  Nature Genetics · 2009 · 10.1038/ng.317

• Recent Advances in Cancer Therapy: An Overview

  Current Pharmaceutical Design · 2009 · https://doi.org/10.2174/138161210789941847

• Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21

  Nature Genetics · 2008 · https://doi.org/10.1038/ng.133

• Guidelines for the clinical management of familial adenomatous polyposis (FAP)

  Gut · 2008 · https://doi.org/10.1136/gut.2007.136127

• Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer)

  Journal of Medical Genetics · 2007 · https://doi.org/10.1136/jmg.2007.048991

• Polymorphisms in Genes of Nucleotide and Base Excision Repair: Risk and Prognosis of Colorectal Cancer

  Clinical Cancer Research · 2006 · 10.1158/1078-0432.ccr-05-1363

• Chromosomal Instability Correlates with Genome-wide DNA Demethylation in Human Primary Colorectal Cancers

  Cancer Research · 2006 · 10.1158/0008-5472.can-06-0293

• Association of common polymorphisms in inflammatory genes interleukin (IL)6, IL8, tumor necrosis factor alpha, NFKB1, and peroxisome proliferator-activated receptor gamma with colorectal cancer.

  PubMed · 2003

• Genetic susceptibility and gastric cancer risk

  International Journal of Cancer · 2002 · 10.1002/ijc.10466

• Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis.

  PubMed · 2001

• Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status.

  PubMed · 2000

• Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.

  PubMed · 2000

• Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.

  PubMed · 2000

• K-ras Mutations in DNA Extracted From the Plasma of Patients With Pancreatic Carcinoma: Diagnostic Utility and Prognostic Significance

  Journal of Clinical Oncology · 1999 · https://doi.org/10.1200/jco.1999.17.2.578

Current projects

No projects listed.